Mechanisms of botulinum toxin type A action on pain

I Matak, K Bölcskei, L Bach-Rojecky, Z Helyes - Toxins, 2019 - mdpi.com
Already a well-established treatment for different autonomic and movement disorders, the
use of botulinum toxin type A (BoNT/A) in pain conditions is now continuously expanding …

Botulinum toxin for the treatment of neuropathic pain

JH Park, HJ Park - Toxins, 2017 - mdpi.com
Botulinum toxin (BoNT) has been used as a treatment for excessive muscle stiffness,
spasticity, and dystonia. BoNT for approximately 40 years, and has recently been used to …

Efficacy and safety of botulinum toxin type A on persistent myofascial pain: A randomized clinical trial

G De la Torre Canales, N Alvarez-Pinzon… - Toxins, 2020 - mdpi.com
This study assessed the safety and efficacy of three different doses of BoNT-A for persistent
myofascial pain (MFP). One hundred female subjects were randomly assigned into five …

Botulinum toxin treatment of pain syndromes–an evidence based review

Y Safarpour, B Jabbari - Toxicon, 2018 - Elsevier
This review evaluates the existing level of evidence for efficacy of BoNTs in different pain
syndromes using the recommended efficacy criteria from the Assessment and Therapeutic …

Subcutaneous injection of botulinum toxin a is beneficial in postherpetic neuralgia

L **ao, S Mackey, H Hui, D Xong, Q Zhang… - Pain …, 2010 - academic.oup.com
Objective. To assess the benefits of subcutaneous injection of botulinum toxin A (BTX-A) for
the treatment of postherpetic neuralgia (PHN). Design. We investigated the therapeutic …

Botulinum toxin for neuropathic pain: a review of the literature

HM Oh, ME Chung - Toxins, 2015 - mdpi.com
Botulinum neurotoxin (BoNT), derived from Clostridium botulinum, has been used
therapeutically for focal dystonia, spasticity, and chronic migraine. Its spectrum as a potential …

Botulinum toxin-A effects on pain, somatosensory and psychosocial features of patients with refractory masticatory myofascial pain: a randomized double-blind clinical …

G De la Torre Canales, RL Poluha, LR Bonjardim… - Scientific Reports, 2024 - nature.com
The antinociceptive effect of BoNT-A have been well documented in animal studies;
however, results of few but well-designed randomized placebo-controlled clinical trials …

Behavioral and immunohistochemical evidence for central antinociceptive activity of botulinum toxin A

I Matak, L Bach-Rojecky, B Filipović, Z Lacković - Neuroscience, 2011 - Elsevier
Abstract Botulinum toxin A (BTX-A) is approved for treatment of different cholinergic
hyperactivity disorders, and, recently, migraine headache. Although suggested to act only …

Botulinum toxin A, brain and pain

I Matak, Z Lacković - Progress in neurobiology, 2014 - Elsevier
Botulinum neurotoxin type A (BoNT/A) is one of the most potent toxins known and a potential
biological threat. At the same time, it is among the most widely used therapeutic proteins …

Evidence-based knee injections for the management of arthritis

OT Cheng, D Souzdalnitski, B Vrooman… - Pain medicine, 2012 - academic.oup.com
Objective. Arthritis of the knee affects 46 million Americans. We aimed to determine the level
of evidence of intraarticular knee injections in the management of arthritic knee pain …