The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

The endocannabinoid signaling system regulates diverse physiologic processes and has
attracted considerable attention as a potential pharmaceutical target for treating diseases …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

This article presents several covalent inhibitors, including examples of successful drugs, as
well as highly selective, irreversible inhibitors of emerging therapeutic targets, such as fatty …

Endocannabinoids are lipid signaling molecules that regulate a wide range of mammalian
behaviors, including pain, inflammation, and cognitive/emotional state. The …

The endocannabinoids are lipid-derived messengers that play a diversity of regulatory roles
in mammalian physiology. Dysfunctions in their activity have been implicated in various …

Background: Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme that
hydrolyzes the endocannabinoid anandamide and related amidated signaling lipids …

Fatty acid amide hydrolase (FAAH) is an integral membrane serine hydrolase that degrades
the fatty acid amide family of signaling lipids, including the endocannabinoid anandamide …

Fatty acid ethanolamides (FAEs) and endocannabinoids (ECs) have been shown to
alleviate pain and inflammation, regulate motility and appetite, and produce anticancer …

The omega-3 fatty acid ethanolamides, docosahexaenoyl ethanolamide (DHEA) and
eicosapentaenoyl ethanolamide (EPEA), displayed greater anti-proliferative potency than …