Virtually every eukaryotic cell has an endogenous circadian clock and a biological sex.
These cell-based clocks have been conceptualized as oscillators whose phase can be reset …

Daily and seasonal rhythms in the endocrine system are co-ordinated by a hypothalamic
pacemaker, the suprachiasmatic nuclei (SCN) that is synchronised to solar time by direct …

Sleep is an evolutionarily conserved behavioral state whose regulation is poorly
understood. A classical model posits that sleep is regulated by homeostatic and circadian …

Circadian rhythms in mammals are governed by the hypothalamic suprachiasmatic nucleus
(SCN), in which 20,000 clock cells are connected together into a powerful time‐kee** …

Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and
metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals …

It has been known for a long time that genetic factors affect sleep quantity and quality.
Genetic screens have identified several mutations that affect sleep across species, pointing …

Background Imbalances in amount and timing of sleep are harmful to physical and mental
health. Therefore, the study of the underlying mechanisms is of great biological importance …

Sleep is an essential process conserved from flies to humans. The importance of sleep is
underscored by its tight homeostatic control. Through a forward genetic screen, we identified …

Background Numerous studies suggest genetic influences on sleepiness and circadian
rhythms. The Sleep Heart Health Study collected questionnaire data on sleep habits and …

The endogenous circadian clock modulates cognitive performance over the daily 24-h cycle.
Environmental disturbance of the clock, such as shift work or jet lag schedules, compromises …