Introduction: The close relationship existing between aging and thrombosis has growingly
been studied in this last decade. The age‐related development of a prothrombotic …

Activation of the fibrinolytic system is dependent on the conversion of the plasma zymogen,
plasminogen (Pg), to the serine protease plasmin (Pm) by the physiological activators …

Inflammation plays a critical role in the development of cardiovascular diseases. Infiltration
of leukocytes to sites of injury requires their exit from the blood and migration across …

Highlights•Plasminogen initially binds C-terminal lysine containing receptors through kringle
1.•Plasminogen conformational change is triggered through lysine binding to kringle …

The fibrinolytic system includes a broad spectrum of proteolytic enzymes with physiological
and pathophysiological functions in several processes, such as haemostatic balance, tissue …

A bidirectional association exists between metastatic dissemination and the
hypercoagulable state associated with many types of cancer. As such, clinical studies have …

Bacteria do not simply express a constitutive panel of proteins but they instead undergo
dynamic changes in their protein repertoire in response to changes in nutritional status and …

The interaction with the host plasminogen/plasmin system represents a novel component in
the molecular cross-talk between bifidobacteria and human host. Here, we demonstrated …

Fibrosis is characterized by excessive accumulation of extracellular matrix (ECM) in
basement membranes and interstitial tissues, resulting from increased synthesis or …

The main physiological functions of plasmin, the active form of its proenzyme plasminogen,
are blood clot fibrinolysis and restoration of normal blood flow. The plasminogen activation …