Population genomic analyses of high-altitude humans and other vertebrates have identified
numerous candidate genes for hypoxia adaptation, and the physiological pathways …

To cope with the reduced availability of O2 at high altitude, air-breathing vertebrates have
evolved myriad adjustments in the cardiorespiratory system to match tissue O2 delivery with …

In mammals and other air-breathing vertebrates that live at high altitude, adjustments in
convective O 2 transport via changes in blood hemoglobin (Hb) content and/or Hb-O 2 …

Global temperature changes have emphasized the need to understand how species adapt
to thermal stress across their ranges. Genetic mechanisms may contribute to variation in …

Key points Mitochondrial function changes over time at high altitudes, but the potential
benefits of these changes for hypoxia resistance remains unclear. We used high‐altitude …

Comparative physiology studies of high-altitude species provide an exceptional opportunity
to understand naturally evolved mechanisms of hypoxia resistance. Aerobic capacity …

Population genomic studies of humans and other animals at high altitude have generated
many hypotheses about the genes and pathways that may have contributed to hypoxia …

High-altitude environments present strong stresses for living organisms, which have driven
striking phenotypic and genetic adaptations. While previous studies have revealed multiple …

Hypoxia, defined as a reduced oxygen availability, can be observed in many tissues in
response to various physiological and pathological conditions. As a hallmark of the altitude …

Evolutionary adaptation to extreme environments often requires coordinated changes in
multiple intersecting physiological pathways, but how such multi-trait adaptation occurs …