[HTML][HTML] Insulin and insulin resistance in Alzheimer's disease

A Sędzikowska, L Szablewski - International journal of molecular sciences, 2021 - mdpi.com
Insulin plays a range of roles as an anabolic hormone in peripheral tissues. It regulates
glucose metabolism, stimulates glucose transport into cells and suppresses hepatic glucose …

[HTML][HTML] Gender differences in insulin resistance: new knowledge and perspectives

T Ciarambino, P Crispino, G Guarisco… - Current Issues in …, 2023 - mdpi.com
Insulin resistance is the main mechanism in a whole series of pathological conditions, which
are not only of metabolic interest but also of a systemic type. This phenomenon means that …

Prediabetes increases the risk of frailty in prefrail older adults with hypertension: beneficial effects of metformin

G Santulli, V Visco, F Varzideh, G Guerra… - …, 2024 - ahajournals.org
BACKGROUND: Prediabetes has garnered increasing attention due to its association with
cardiovascular conditions, especially hypertension, which heightens the risk of prefrailty and …

Brain uptake pharmacokinetics of albiglutide, dulaglutide, tirzepatide, and DA5-CH in the search for new treatments of Alzheimer's and Parkinson's diseases

EM Rhea, A Babin, P Thomas, M Omer, R Weaver… - Tissue …, 2024 - Taylor & Francis
Background A number of peptide incretin receptor agonists (IRAs) show promise as
therapeutics for Alzheimer's disease (AD) and Parkinson's disease (PD). Transport across …

Estrogens and the regulation of glucose metabolism

M Alemany - World Journal of diabetes, 2021 - pmc.ncbi.nlm.nih.gov
The main estrogens: estradiol, estrone, and their acyl-esters have been studied essentially
related to their classical estrogenic and pharmacologic functions. However, their main effect …

Recent development in the understanding of molecular and cellular mechanisms underlying the etiopathogenesis of Alzheimer's disease

A Afsar, MC Chacon Castro, AS Soladogun… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to
dementia and patient death. AD is characterized by intracellular neurofibrillary tangles …

NM101 Phase III study of NE3107 in Alzheimer's disease: rationale, design and therapeutic modulation of neuroinflammation and insulin resistance

CL Reading, CN Ahlem, MF Murphy - Neurodegenerative Disease …, 2021 - Taylor & Francis
Recently, the roles of inflammation and insulin resistance in neurodegeneration have
become better appreciated. NE3107, an oral small molecule, blood-brain permeable anti …

[HTML][HTML] Brain glucose transporters: role in pathogenesis and potential targets for the treatment of Alzheimer's disease

L Szablewski - International Journal of Molecular Sciences, 2021 - mdpi.com
The most common cause of dementia, especially in elderly people, is Alzheimer's disease
(AD), with aging as its main risk factor. AD is a multifactorial neurodegenerative disease …

Alternative role of glucagon-like Peptide-1 receptor agonists in neurodegenerative diseases

SD Chen, YC Chuang, TK Lin, JL Yang - European journal of …, 2023 - Elsevier
Aging is a crucial risk factor for common neurodegenerative diseases, such as Alzheimer's
disease (AD) and Parkinson's disease (PD). Limited options are available for the treatment …

[HTML][HTML] Comparative Antioxidant, Anti-Acetylcholinesterase and Anti-α-Glucosidase Activities of Mediterranean Salvia Species

M Mervić, M Bival Štefan, M Kindl, B Blažeković… - Plants, 2022 - mdpi.com
Salvia species have a cosmopolitan distribution and comprise several well-known plants
valuable for pharmaceutical and food industries due to their recognized medicinal, food …