How does adenosine control neuronal dysfunction and neurodegeneration?

RA Cunha - Journal of neurochemistry, 2016 - Wiley Online Library
The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

Are cannabidiol and Δ9‐tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

JM McPartland, M Duncan, V Di Marzo… - British journal of …, 2015 - Wiley Online Library
Based upon evidence that the therapeutic properties of C annabis preparations are not
solely dependent upon the presence of Δ9‐tetrahydrocannabinol (THC), pharmacological …

Adenosine receptors: expression, function and regulation

S Sheth, R Brito, D Mukherjea, LP Rybak… - International journal of …, 2014 - mdpi.com
Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which
mediate the physiological actions of adenosine. To date, four AR subtypes have been …

Contribution of axonal orientation to pathway-dependent modulation of excitatory transmission by direct current stimulation in isolated rat hippocampus

AY Kabakov, PA Muller… - Journal of …, 2012 - journals.physiology.org
Transcranial direct current stimulation (tDCS) is a method for modulating cortical excitability
by weak constant electrical current that is applied through scalp electrodes. Although often …

The role of adenosine A2A receptors in Alzheimer's disease and tauopathies

A Launay, O Nebie, JV Shankara, T Lebouvier… - …, 2023 - Elsevier
Adenosine signals through four distinct G protein-coupled receptors that are located at
various synapses, cell types and brain areas. Through them, adenosine regulates …

Ecto-5′-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions

E Augusto, M Matos, J Sévigny, A El-Tayeb… - Journal of …, 2013 - jneurosci.org
Adenosine is a neuromodulator acting through inhibitory A1 receptors (A1Rs) and facilitatory
A2ARs, which have similar affinities for adenosine. It has been shown that the activity of …

Purinergic signaling orchestrating neuron-glia communication

P Agostinho, D Madeira, L Dias, AP Simões… - Pharmacological …, 2020 - Elsevier
This review discusses the evidence supporting a role for ATP signaling (operated by P 2 X
and P 2 Y receptors) and adenosine signaling (mainly operated by A 1 and A 2A receptors) …

[HTML][HTML] Striatopallidal adenosine A2A receptor modulation of goal-directed behavior: Homeostatic control with cognitive flexibility

JF Chen, DS Choi, RA Cunha - Neuropharmacology, 2023 - Elsevier
Dysfunction of goal-directed behaviors under stressful or pathological conditions results in
impaired decision-making and loss of flexibility of thoughts and behaviors, which underlie …

Adenosine receptor neurobiology: overview

JF Chen, C Lee, Y Chern - International review of neurobiology, 2014 - Elsevier
Adenosine is a naturally occurring nucleoside that is distributed ubiquitously throughout the
body as a metabolic intermediary. In the brain, adenosine functions as an important …

Cannabis: a treasure trove or pandora's box?

K Solymosi, A Köfalvi - Mini reviews in medicinal chemistry, 2017 - benthamdirect.com
Background & Objective: Cannabis is one of the earliest cultivated plants. Cannabis of
industrial utility and culinary value is generally termed as hemp. Conversely, cannabis that is …