Sex differences in stroke: challenges and opportunities

CD Bushnell, S Chaturvedi, KR Gage… - Journal of Cerebral …, 2018 - journals.sagepub.com
Biologic sex influences many variables that are important to brain health in general, and to
stroke or cerebral ischemia in particular, such as general health status, cerebrovascular …

[HTML][HTML] Considering sex as a biological variable in preclinical research

LR Miller, C Marks, JB Becker, PD Hurn… - The FASEB …, 2016 - pmc.ncbi.nlm.nih.gov
In June 2015, the National Institutes of Health (NIH) released a Guide notice (NOT-OD-15-
102) that highlighted the expectation of the NIH that the possible role of sex as a biologic …

Policy: NIH to balance sex in cell and animal studies

JA Clayton, FS Collins - Nature, 2014 - nature.com
Policy: NIH to balance sex in cell and animal studies | Nature Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

Sex differences in cognitive impairment and Alzheimer's disease

R Li, M Singh - Frontiers in neuroendocrinology, 2014 - Elsevier
Studies have shown differences in specific cognitive ability domains and risk of Alzheimer's
disease between the men and women at later age. However it is important to know that sex …

[HTML][HTML] Studying both sexes: a guiding principle for biomedicine

JA Clayton - The FASEB Journal, 2015 - pmc.ncbi.nlm.nih.gov
In May 2014, the US National Institutes of Health (NIH) announced that it will ensure that
investigators account for sex as a biological variable (SABV) in NIH-funded preclinical …

Neonatal encephalopathy: an inadequate term for hypoxic–ischemic encephalopathy

JJ Volpe - Annals of neurology, 2012 - Wiley Online Library
Abstract This Point of View article addresses neonatal encephalopathy (NE) presumably
caused by hypoxia–ischemia and the terminology currently in wide use for this disorder. The …

Therapeutic applications of PARP inhibitors: anticancer therapy and beyond

NJ Curtin, C Szabo - Molecular aspects of medicine, 2013 - Elsevier
The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

Traumatic brain injury in older adults: epidemiology, outcomes, and future implications

HJ Thompson, WC McCormick… - Journal of the American …, 2006 - Wiley Online Library
Traumatic brain injury (TBI) is a significant problem in older adults. In persons aged 65 and
older, TBI is responsible for more than 80,000 emergency department visits each year; three …

Opportunities for the repurposing of PARP inhibitors for the therapy of non‐oncological diseases

NA Berger, VC Besson, AH Boulares… - British journal of …, 2018 - Wiley Online Library
The recent clinical availability of the PARP inhibitor olaparib (Lynparza) opens the door for
potential therapeutic repurposing for non‐oncological indications. Considering (a) the …

[HTML][HTML] Drug-induced liver injury: Interactions between drug properties and host factors

M Chen, A Suzuki, J Borlak, RJ Andrade… - Journal of hepatology, 2015 - Elsevier
Idiosyncratic drug-induced liver injury (DILI) is a common cause for drug withdrawal from the
market and although infrequent, DILI can result in serious clinical outcomes including acute …