[HTML][HTML] Liquid-liquid phase separation of nucleocapsid proteins during SARS-CoV-2 and HIV-1 replication

BA Chau, V Chen, AW Cochrane, LJ Parent… - Cell reports, 2023 - cell.com
The leap of retroviruses and coronaviruses from animal hosts to humans has led to two
ongoing pandemics and tens of millions of deaths worldwide. Retrovirus and coronavirus …

The role of SARS-CoV-2 N protein in diagnosis and vaccination in the context of emerging variants: Present status and prospects

W Song, Z Fang, F Ma, J Li, Z Huang, Y Zhang… - Frontiers in …, 2023 - frontiersin.org
Despite many countries rapidly revising their strategies to prevent contagions, the number of
people infected with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

A specific phosphorylation-dependent conformational switch in SARS-CoV-2 nucleocapsid protein inhibits RNA binding

M Botova, AR Camacho-Zarco, J Tognetti… - Science …, 2024 - science.org
The nucleocapsid protein of severe acute respiratory syndrome coronavirus 2 encapsidates
the viral genome and is essential for viral function. The central disordered domain comprises …

Dipolar Recoupling in Rotating Solids

V Ladizhansky, RS Palani, M Mardini… - Chemical …, 2024 - ACS Publications
Magic angle spinning (MAS) nuclear magnetic resonance (NMR) has evolved significantly
over the past three decades and established itself as a vital tool for the structural analysis of …

Molecular characterization of SARS-CoV-2 nucleocapsid protein

Y Huang, J Chen, S Chen, C Huang, B Li… - Frontiers in Cellular …, 2024 - frontiersin.org
Corona Virus Disease 2019 (COVID-19) is a highly prevalent and potent infectious disease
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Until now, the …

1H-detected characterization of carbon–carbon networks in highly flexible protonated biomolecules using MAS NMR

S Bahri, A Safeer, A Adler, H Smedes… - Journal of Biomolecular …, 2023 - Springer
In the last three decades, the scope of solid-state NMR has expanded to exploring complex
biomolecules, from large protein assemblies to intact cells at atomic-level resolution. This …

Cryo-EM and cryo-ET of the spike, virion, and antibody neutralization of SARS-CoV-2 and VOCs

C Xu, W Han, Y Cong - Current Opinion in Structural Biology, 2023 - Elsevier
Since the outbreak of the COVID-19 pandemic, cryo-electron microscopy (cryo-EM) and cryo-
electron tomography (cryo-ET) have been demonstrated to be powerful and efficient tools in …

Expanding the tool box for native structural biology: 19F dynamic nuclear polarization with fast magic angle spinning

KT Movellan, W Zhu, D Banks, J Kempf, B Runge… - Science …, 2024 - science.org
Obtaining atomic-level information on components in the cell is a major focus in structural
biology. Elucidating specific structural and dynamic features of proteins and their …

Targeting viral suppressor of RNAi confers anti-coronaviral activity

J Chen, JF Mu, K Zhou, Y Zhang, J Zhang, T Shu… - Molecular Therapy, 2025 - cell.com
Infections caused by coronaviruses are persistent threats to human health in recent
decades, necessitating the development of innovative anti-coronaviral therapies. RNA …

SERS-active immunoassay kit for SARS-CoV‑2 mediated by the cooperative chemical and electromagnetic effects of MXene modified with gold nanowires

C Wang, J Han, D Xue, C Gu, S Zeng, J Jiang… - … Acta Part A: Molecular …, 2024 - Elsevier
Surface-enhanced Raman scattering (SERS) technique with high sensitivity, reliable
specificity, and rapid recognition ability exhibits attractive promise for the effective fast …