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Tissue damaging toxins in snake venoms: mechanisms of action, pathophysiology and treatment strategies
Snakebite envenoming is an important public health issue responsible for mortality and
severe morbidity. Where mortality is mainly caused by venom toxins that induce …
severe morbidity. Where mortality is mainly caused by venom toxins that induce …
[HTML][HTML] Inflammation and oxidative stress in snakebite envenomation: a brief descriptive review and clinical implications
Snakebite envenoming is a pathological condition which may occur in response to the
injection of venom. Snake venoms contain a complex mixture of biologically active …
injection of venom. Snake venoms contain a complex mixture of biologically active …
Molecular dissection of cobra venom highlights heparinoids as an antidote for spitting cobra envenoming
Snakebites affect about 1.8 million people annually. The current standard of care involves
antibody-based antivenoms, which can be difficult to access and are generally not effective …
antibody-based antivenoms, which can be difficult to access and are generally not effective …
Progress and challenges in the field of snakebite envenoming therapeutics
JM Gutiérrez, N R. Casewell… - Annual Review of …, 2024 - annualreviews.org
Snakebite envenoming kills and maims hundreds of thousands of people every year,
especially in the rural settings of tropical regions. Envenomings are still treated with animal …
especially in the rural settings of tropical regions. Envenomings are still treated with animal …
Plant-derived toxin inhibitors as potential candidates to complement antivenom treatment in snakebite envenomations
AAX Adrião, AO Dos Santos, EJSP de Lima… - Frontiers in …, 2022 - frontiersin.org
Snakebite envenomations (SBEs) are a neglected medical condition of global importance
that mainly affect the tropical and subtropical regions. Clinical manifestations include pain …
that mainly affect the tropical and subtropical regions. Clinical manifestations include pain …
Differential effects of the venoms of Russell's viper and Indian cobra on human myoblasts
Local tissue damage following snakebite envenoming remains a poorly researched area. To
develop better strategies to treat snakebites, it is critical to understand the mechanisms …
develop better strategies to treat snakebites, it is critical to understand the mechanisms …
Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors
RH Clare, CA Dawson, A Westhorpe… - Frontiers in …, 2024 - frontiersin.org
Snakebite envenoming results in∼ 100,000 deaths per year, with close to four times as
many victims left with life-long sequelae. Current antivenom therapies have several …
many victims left with life-long sequelae. Current antivenom therapies have several …
[HTML][HTML] Cerebral complications of snakebite envenoming: case studies
YK Huang, YC Chen, CC Liu, HC Cheng, AT Tu… - Toxins, 2022 - mdpi.com
There are an estimated 5.4 million snakebite cases every year. People with snakebite
envenoming suffer from severe complications, or even death. Although some review articles …
envenoming suffer from severe complications, or even death. Although some review articles …
Landscape of toxin-neutralizing therapeutics for snakebite envenoming (2015–2022): Setting the stage for an R&D agenda
J Borri, JM Gutiérrez, C Knudsen… - PLoS neglected …, 2024 - journals.plos.org
Background Progress in snakebite envenoming (SBE) therapeutics has suffered from a
critical lack of data on the research and development (R&D) landscape. A database …
critical lack of data on the research and development (R&D) landscape. A database …
[HTML][HTML] Exploring the utility of recombinant snake venom serine protease toxins as immunogens for generating experimental snakebite antivenoms
N Alomran, P Blundell, J Alsolaiss, E Crittenden… - Toxins, 2022 - mdpi.com
Snakebite is a neglected tropical disease that causes high rates of global mortality and
morbidity. Although snakebite can cause a variety of pathologies in victims, haemotoxic …
morbidity. Although snakebite can cause a variety of pathologies in victims, haemotoxic …