Tissue damaging toxins in snake venoms: mechanisms of action, pathophysiology and treatment strategies

MA Bittenbinder, J van Thiel, FC Cardoso… - Communications …, 2024 - nature.com
Snakebite envenoming is an important public health issue responsible for mortality and
severe morbidity. Where mortality is mainly caused by venom toxins that induce …

[HTML][HTML] Inflammation and oxidative stress in snakebite envenomation: a brief descriptive review and clinical implications

D Resiere, H Mehdaoui, R Neviere - Toxins, 2022 - mdpi.com
Snakebite envenoming is a pathological condition which may occur in response to the
injection of venom. Snake venoms contain a complex mixture of biologically active …

Molecular dissection of cobra venom highlights heparinoids as an antidote for spitting cobra envenoming

TY Du, SR Hall, F Chung, S Kurdyukov… - Science Translational …, 2024 - science.org
Snakebites affect about 1.8 million people annually. The current standard of care involves
antibody-based antivenoms, which can be difficult to access and are generally not effective …

Progress and challenges in the field of snakebite envenoming therapeutics

JM Gutiérrez, N R. Casewell… - Annual Review of …, 2024 - annualreviews.org
Snakebite envenoming kills and maims hundreds of thousands of people every year,
especially in the rural settings of tropical regions. Envenomings are still treated with animal …

Plant-derived toxin inhibitors as potential candidates to complement antivenom treatment in snakebite envenomations

AAX Adrião, AO Dos Santos, EJSP de Lima… - Frontiers in …, 2022 - frontiersin.org
Snakebite envenomations (SBEs) are a neglected medical condition of global importance
that mainly affect the tropical and subtropical regions. Clinical manifestations include pain …

Differential effects of the venoms of Russell's viper and Indian cobra on human myoblasts

H Bin Haidar, JR Almeida, J Williams, B Guo, A Bigot… - Scientific reports, 2024 - nature.com
Local tissue damage following snakebite envenoming remains a poorly researched area. To
develop better strategies to treat snakebites, it is critical to understand the mechanisms …

Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors

RH Clare, CA Dawson, A Westhorpe… - Frontiers in …, 2024 - frontiersin.org
Snakebite envenoming results in∼ 100,000 deaths per year, with close to four times as
many victims left with life-long sequelae. Current antivenom therapies have several …

[HTML][HTML] Cerebral complications of snakebite envenoming: case studies

YK Huang, YC Chen, CC Liu, HC Cheng, AT Tu… - Toxins, 2022 - mdpi.com
There are an estimated 5.4 million snakebite cases every year. People with snakebite
envenoming suffer from severe complications, or even death. Although some review articles …

Landscape of toxin-neutralizing therapeutics for snakebite envenoming (2015–2022): Setting the stage for an R&D agenda

J Borri, JM Gutiérrez, C Knudsen… - PLoS neglected …, 2024 - journals.plos.org
Background Progress in snakebite envenoming (SBE) therapeutics has suffered from a
critical lack of data on the research and development (R&D) landscape. A database …

[HTML][HTML] Exploring the utility of recombinant snake venom serine protease toxins as immunogens for generating experimental snakebite antivenoms

N Alomran, P Blundell, J Alsolaiss, E Crittenden… - Toxins, 2022 - mdpi.com
Snakebite is a neglected tropical disease that causes high rates of global mortality and
morbidity. Although snakebite can cause a variety of pathologies in victims, haemotoxic …