We have long known that lipids traffic between cellular membranes via vesicles but have
only recently appreciated the role of nonvesicular lipid transport. Nonvesicular transport can …

Phosphoinositides (PI s) form a minor class of phospholipids with crucial functions in cell
physiology, ranging from cell signalling and motility to a role as signposts of compartmental …

Upon starvation, cells rewire their metabolism, switching from glucose-based metabolism to
mitochondrial oxidation of fatty acids, which require the transfer of FAs from lipid droplets …

Cholesterol is an essential component of metazoan cellular membranes and it helps to
maintain the structural integrity and fluidity of the plasma membrane. Here, we developed a …

Many plasma membrane (PM) functions depend on the cholesterol concentration in the PM
in strikingly nonlinear, cooperative ways: fully functional in the presence of physiological …

Lipids play crucial roles as structural elements, signaling molecules and material
transporters in cells. However, the functions and dynamics of lipids within cells remain …

Specific lipid species play central roles in cell biology. Their presence or enrichment in
individual membranes can control properties or direct protein localization and/or activity …

The concept of transient nanometric domains known as lipid rafts has brought interest to
reassess the validity of the Singer–Nicolson model of a fluid bilayer for cell membranes …

Platelets protect the vascular system during damage or inflammation, but platelet activation
can result in pathological thrombosis. Activated platelets release a variety of extracellular …

Lipids convey both structural and functional properties to eukaryotic membranes.
Understanding the basic lipid composition and the dynamics of these important molecules …