Ketamine, a drug introduced in the 1960s as an anesthetic agent and still used for that
purpose, has garnered marked interest over the past two decades as an emerging treatment …

The subdivisions of the anterior cingulate cortex (ACC)–including subgenual, perigenual
and dorsal zones–are implicated in the etiology, pathogenesis and treatment of major …

Objective: Research has suggested that subanesthetic doses of ketamine may work to
improve cocaine-related vulnerabilities and facilitate efforts at behavioral modification. The …

Objective: Pharmacotherapy and behavioral treatments for alcohol use disorder are limited
in their effectiveness, and new treatments with innovative mechanisms would be valuable. In …

Background: Neuroimaging studies have just begun to explore the acute effects of
psychedelics on large-scale brain networks' functional organization. Even less is known …

There is accumulating evidence demonstrating that dysfunction of glutamatergic
neurotransmission, particularly via N-methyl-d-aspartate (NMDA) receptors, is involved in …

Given that available antidepressant pharmacotherapies are not optimally effective, there is a
need for alternative treatment options that are rooted in a comprehensive understanding of …

Major depressive disorder (MDD) is one of the most prevalent conditions in psychiatry.
Patients who do not respond to traditional monoaminergic antidepressant treatments have …

Ketamine is a highly effective antidepressant (AD) that targets the glutamatergic system and
exerts profound effects on brain circuits during negative emotional processing. Interestingly …

Rumination is a maladaptive style of regulating thoughts and emotions. It is a common
symptom of Major Depressive Disorder (MDD), and more severe rumination is associated …