Major recent advances and previous data have led to a plausible model of how key proteins
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …

Dopamine is a prototypical neuromodulator that controls circuit function through G protein-
coupled receptor signalling. Neuromodulators are volume transmitters, with release followed …

A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein …

Action potentials trigger neurotransmitter release at the presynaptic active zone with
spatiotemporal precision. This is supported by protein machinery that mediates synaptic …

During an action potential, Ca 2+ entering a presynaptic terminal triggers synaptic vesicle
exocytosis and neurotransmitter release in less than a millisecond. How does Ca 2+ …

At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft,
and postsynaptic specialization form a transcellular unit to enable efficient transmission of …

Neurotransmitters are released by synaptic vesicle exocytosis at the active zone of a
presynaptic nerve terminal. In this review, I discuss the molecular composition and function …

Sensory experience remodels neural circuits in the early postnatal brain through
mechanisms that remain to be elucidated. Applying a new method of ultrastructural analysis …

Synaptic vesicle docking, priming, and fusion at active zones are orchestrated by a complex
molecular machinery. We employed hippocampal organotypic slice cultures from mice …

Dopamine controls essential brain functions through volume transmission. Different from fast
synaptic transmission, where neurotransmitter release and receptor activation are tightly …