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The coming decade in precision oncology: six riddles
High-throughput methods to investigate tumour omic landscapes have quickly catapulted
cancer specialists into the precision oncology era. The singular lesson of precision oncology …
cancer specialists into the precision oncology era. The singular lesson of precision oncology …
The main theories on the pathogenesis of endometriosis
J Lamceva, R Uljanovs, I Strumfa - International journal of molecular …, 2023 - mdpi.com
Endometriosis is a complex disease, which is defined by abnormal growth of endometrial
tissue outside the uterus. It affects about 10% of women of reproductive age all over the …
tissue outside the uterus. It affects about 10% of women of reproductive age all over the …
Endometriosis: Etiology, pathobiology, and therapeutic prospects
Endometriosis is a common condition associated with infertility that causes chronic pain in
many, but not all, women. It is defined by the presence of endometrial-like tissue outside the …
many, but not all, women. It is defined by the presence of endometrial-like tissue outside the …
Endometriosis is a chronic systemic disease: clinical challenges and novel innovations
HS Taylor, AM Kotlyar, VA Flores - The Lancet, 2021 - thelancet.com
Endometriosis is a common disease affecting 5–10% of women of reproductive age globally.
However, despite its prevalence, diagnosis is typically delayed by years, misdiagnosis is …
However, despite its prevalence, diagnosis is typically delayed by years, misdiagnosis is …
Single-cell transcriptomic analysis of endometriosis
Endometriosis is a common condition in women that causes chronic pain and infertility and
is associated with an elevated risk of ovarian cancer. We profiled transcriptomes of> …
is associated with an elevated risk of ovarian cancer. We profiled transcriptomes of> …
[HTML][HTML] Menstruation: science and society
Women's health concerns are generally underrepresented in basic and translational
research, but reproductive health in particular has been hampered by a lack of …
research, but reproductive health in particular has been hampered by a lack of …
Genetic variation across and within individuals
Germline variation and somatic mutation are intricately connected and together shape
human traits and disease risks. Germline variants are present from conception, but they vary …
human traits and disease risks. Germline variants are present from conception, but they vary …
Somatic mutant clones colonize the human esophagus with age
The extent to which cells in normal tissues accumulate mutations throughout life is poorly
understood. Some mutant cells expand into clones that can be detected by genome …
understood. Some mutant cells expand into clones that can be detected by genome …
[HTML][HTML] The emerging role of cell-free DNA as a molecular marker for cancer management
An increasing number of studies demonstrate the potential use of cell-free DNA (cfDNA) as a
surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …
surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …
The origin and pathogenesis of endometriosis
Recent molecular genetic findings on endometriosis and normal endometrium suggest a
modified model in which circulating epithelial progenitor or stem cells intended to …
modified model in which circulating epithelial progenitor or stem cells intended to …