The coming decade in precision oncology: six riddles

A Wahida, L Buschhorn, S Fröhling, PJ Jost… - Nature Reviews …, 2023 - nature.com
High-throughput methods to investigate tumour omic landscapes have quickly catapulted
cancer specialists into the precision oncology era. The singular lesson of precision oncology …

The main theories on the pathogenesis of endometriosis

J Lamceva, R Uljanovs, I Strumfa - International journal of molecular …, 2023 - mdpi.com
Endometriosis is a complex disease, which is defined by abnormal growth of endometrial
tissue outside the uterus. It affects about 10% of women of reproductive age all over the …

Endometriosis: Etiology, pathobiology, and therapeutic prospects

PTK Saunders, AW Horne - Cell, 2021 - cell.com
Endometriosis is a common condition associated with infertility that causes chronic pain in
many, but not all, women. It is defined by the presence of endometrial-like tissue outside the …

Endometriosis is a chronic systemic disease: clinical challenges and novel innovations

HS Taylor, AM Kotlyar, VA Flores - The Lancet, 2021 - thelancet.com
Endometriosis is a common disease affecting 5–10% of women of reproductive age globally.
However, despite its prevalence, diagnosis is typically delayed by years, misdiagnosis is …

Single-cell transcriptomic analysis of endometriosis

MAS Fonseca, M Haro, KN Wright, X Lin, F Abbasi… - Nature …, 2023 - nature.com
Endometriosis is a common condition in women that causes chronic pain and infertility and
is associated with an elevated risk of ovarian cancer. We profiled transcriptomes of> …

[HTML][HTML] Menstruation: science and society

HOD Critchley, E Babayev, SE Bulun, S Clark… - American journal of …, 2020 - Elsevier
Women's health concerns are generally underrepresented in basic and translational
research, but reproductive health in particular has been hampered by a lack of …

Genetic variation across and within individuals

Z Yu, THH Coorens, MM Uddin, KG Ardlie… - Nature Reviews …, 2024 - nature.com
Germline variation and somatic mutation are intricately connected and together shape
human traits and disease risks. Germline variants are present from conception, but they vary …

Somatic mutant clones colonize the human esophagus with age

I Martincorena, JC Fowler, A Wabik, ARJ Lawson… - Science, 2018 - science.org
The extent to which cells in normal tissues accumulate mutations throughout life is poorly
understood. Some mutant cells expand into clones that can be detected by genome …

[HTML][HTML] The emerging role of cell-free DNA as a molecular marker for cancer management

AJ Bronkhorst, V Ungerer, S Holdenrieder - Biomolecular detection and …, 2019 - Elsevier
An increasing number of studies demonstrate the potential use of cell-free DNA (cfDNA) as a
surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …

The origin and pathogenesis of endometriosis

Y Wang, K Nicholes, IM Shih - Annual Review of Pathology …, 2020 - annualreviews.org
Recent molecular genetic findings on endometriosis and normal endometrium suggest a
modified model in which circulating epithelial progenitor or stem cells intended to …