Mechanisms of PTEN loss in cancer: It's all about diversity
V Álvarez-Garcia, Y Tawil, HM Wise… - Seminars in cancer biology, 2019 - Elsevier
PTEN is a phosphatase which metabolises PIP 3, the lipid product of PI 3-Kinase, directly
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …
MicroRNA biogenesis pathways in cancer
S Lin, RI Gregory - Nature reviews cancer, 2015 - nature.com
MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and
overexpression of individual'oncomiRs' or genetic loss of tumour suppressor miRNAs are …
overexpression of individual'oncomiRs' or genetic loss of tumour suppressor miRNAs are …
Micro-RNA: The darkhorse of cancer
The discovery of micro RNAs (miRNA) in cancer has opened up new vistas for researchers
in recent years. Micro RNAs area set of small, endogenous, highly conserved, non-coding …
in recent years. Micro RNAs area set of small, endogenous, highly conserved, non-coding …
Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer
T Liu, X Zhang, L Du, Y Wang, X Liu, H Tian, L Wang… - Molecular cancer, 2019 - Springer
Background Oxaliplatin resistance is a major challenge for treatment of advanced colorectal
cancer (CRC). Both acquisition of epithelial-mesenchymal transition (EMT) and suppressed …
cancer (CRC). Both acquisition of epithelial-mesenchymal transition (EMT) and suppressed …
MicroRNAs in cancer
MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and
stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such …
stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such …
A review of the biological role of miRNAs in prostate cancer suppression and progression
Prostate cancer (PC) is the third-leading cause of cancer-related deaths worldwide.
Although the current treatment strategies are progressing rapidly, PC is still representing a …
Although the current treatment strategies are progressing rapidly, PC is still representing a …
MicroRNAs in development and disease
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …
introduced an additional level of intricacy to our understanding of gene regulation. There are …
Detection of circulating miRNAs: comparative analysis of extracellular vesicle-incorporated miRNAs and cell-free miRNAs in whole plasma of prostate cancer patients
Background Circulating cell-free miRNAs have emerged as promising minimally-invasive
biomarkers for early detection, prognosis and monitoring of cancer. They can exist in the …
biomarkers for early detection, prognosis and monitoring of cancer. They can exist in the …
Causes and consequences of microRNA dysregulation in cancer
Over the past several years it has become clear that alterations in the expression of
microRNA (miRNA) genes contribute to the pathogenesis of most—if not all—human …
microRNA (miRNA) genes contribute to the pathogenesis of most—if not all—human …
Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes
The aim of this study was to identify microRNAs in urinary exosomes that are differently
expressed in prostate cancer patients and healthy donors. For this purpose, RNA was …
expressed in prostate cancer patients and healthy donors. For this purpose, RNA was …