Understanding how individual neurons integrate the thousands of synaptic inputs they
receive is critical to understanding how the brain works. Modeling studies in silico and …

A basic feature of intelligent systems such as the cerebral cortex is the ability to freely
associate aspects of perceived experience with an internal representation of the world and …

Dendritic spines mediate most excitatory neurotransmission in the nervous system, so their
function must be critical for the brain. Spines are biochemical compartments but might also …

The brain has an extraordinary capacity for memory storage, but how it stores new
information without disrupting previously acquired memories remains unknown. Here we …

Neuronal dendrites are electrically excitable: they can generate regenerative events such as
dendritic spikes in response to sufficiently strong synaptic input,,. Although such events have …

One of the central questions in neuroscience is how particular tasks, or computations, are
implemented by neural networks to generate behavior. The prevailing view has been that …

DOMINANT alleles at the agouti locus (A) cause an obesity syndrome in the mouse, as a
consequence of ectopic expression of the agouti peptide1–6. This peptide, normally only …

NEOCORTICAL neurons display a wide range of dendritic morphologies, ranging from
compact arborizations to highly elaborate branching patterns1. In vitro electrical recordings …

Tuft dendrites are the main target for feedback inputs innervating neocortical layer 5
pyramidal neurons, but their properties remain obscure. We report the existence of N-methyl …

Dendrites are the main recipients of synaptic inputs and are important sites that determine
neurons' input-output functions. This review focuses on thin neocortical dendrites, which …