Cyclophilin A (CyPA) is a ubiquitously distributed protein belonging to the immunophilin
family. CyPA has peptidyl prolyl cis-trans isomerase (PPIase) activity, which regulates …

In the cell, as in vitro, the final conformation of a protein is determined by its amino-acid
sequence. But whereas some isolated proteins can be denatured and refolded in vitro in the …

THE structurally novel macrolide FK506 (refs 1, 2) has recently been demonstrated to have
potent immunosuppressive activity3–7 at concentrations several hundredfold lower than …

Cyclosporin A, FK506, and rapamycin are inhibitors of specific signal transduction pathways
that lead to T lymphocyte activation. These immunosuppressive agents bind with high affinity …

Cyclosporine A therapy for prophylaxis against graft rejection revolutionized human organ
transplantation. The immunosuppressant drugs cyclosporin A (CsA), FK506 and rapamycin …

SELF-INCOMPATIBILITY in flowering plants is often controlled by a single nuclear gene (the
S-gene) having several alleles1. This gene prevents fertilization by self-pollen or by pollen …

mRNAs that contain premature stop codons are unstable in most eukaryotes, but the
mechanism of their degradation is largely unknown. We demonstrate that functions of the six …

We have isolated an 18-kDa peptide (designated sp18, for 18-kDa secreted protein) from
the conditioned medium of lipopolysaccharide-stimulated RAW 264.7 murine macrophages …

Two sequence‐unrelated families of proteins possess peptidylproline cis‐trans‐isomerase
activities (PPlase). PPlases are highly sequence conserved and multifunctional proteins …

Mutations in ric‐3 (r esistant to i nhibitors of c holinesterase) suppress the neuronal
degenerations caused by a gain of function mutation in the Caenorhabditis elegans DEG‐3 …