Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

The prevalence of food allergy (FA) is increasing in some areas of the globe, highlighting the
need for better strategies for prevention, diagnosis, and therapy. In the last few decades, we …

Modern health care requires a proactive and individualized response to diseases,
combining precision diagnosis and personalized treatment. Accordingly, the approach to …

The intestinal epithelial tract forms a dynamic lining of the digestive system consisting of a
range of epithelial cell sub-types with diverse functions fulfilling specific niches. The …

Growing evidence points to an important role for the commensal microbiota in susceptibility
to food allergy. Epidemiologic studies demonstrate associations between exposures known …

Objective To review observational human, murine, and interventional trial studies that have
examined the gut microbiome in food allergy, and to provide perspective on future …

Background Childhood-onset and adult-onset asthma differ with respect to severity and
comorbidities. Whether they also differ with respect to genetic risk factors has not been …

Allergic eosinophilic esophagitis (EoE) is a chronic, allergen-mediated inflammatory disease
of the esophagus, and the most common cause of prolonged dysphagia in children and …

Background A genetic defect in the epidermal barrier protein filaggrin (FLG) plays a major
role in the etiology of eczema and associated allergic airways diseases. However, it is still …

Food allergy (FA), a growing public health burden in the United States, and familial
aggregation studies support strong roles for both genes and environment in FA risk …