Introduction Antimicrobial resistance (AMR) is responsible for the death of millions
worldwide and stands as a major threat to our healthcare systems, which are heavily reliant …

Cell-free gene expression (CFE) systems empower synthetic biologists to build biological
molecules and processes outside of living intact cells. The foundational principle is that …

The advent of distributed biomanufacturing platforms promises to increase agility in biologic
production and expand access by reducing reliance on refrigerated supply chains. However …

Glycosylation plays a pivotal role in tuning the folding and function of proteins. Because
most human therapeutic proteins are glycosylated, understanding and controlling …

Vaccines remain one of the most important pillars in preventative medicine, providing
protection against a wide array of diseases by inducing humoral and/or cellular immunity. Of …

The production of N-linked glycoproteins in genetically engineered Escherichia coli holds
significant potential for reducing costs, streamlining bioprocesses, and enhancing …

Diarrheagenic Escherichia coli serotypes are associated with various clinical syndromes, yet
the precise correlation between serotype and pathotype remains unclear. A major barrier to …

Bacterial cells are covered by a complex carbohydrate coat of armor that allows bacteria to
thrive in a range of environments. As a testament to the importance of bacterial glycans …

Glycan-binding receptors known as lectins represent a class of potential therapeutic targets.
Yet, the therapeutic potential of targeting lectins remains largely untapped due in part to …

N-linked glycosylation plays a key role in the efficacy of many therapeutic proteins. One
limitation to the bacterial glycoengineering of human N-linked glycans is the difficulty of …