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Biginelli Reaction: A Multi-Component Type of Reaction and Synthetic Advancement in the Synthesis of Bioactive Dihydropyrimidinone Derivatives
R Ambatwar, V Gupta, S Kumar… - Mini-Reviews in Organic …, 2024 - benthamdirect.com
Background: In synthetic and medicinal chemistry, multi-component reactions (MCRs) are
considered an essential tool in synthesizing bioactive heterocyclic scaffolds. These …
considered an essential tool in synthesizing bioactive heterocyclic scaffolds. These …
Synthesis of dihydropyrimidinones and thiones by multicomponent reactions: strategies beyond the classical Biginelli reaction
JP Wan, Y Liu - Synthesis, 2010 - thieme-connect.com
The three-component Biginelli reaction for the synthesis of dihydropyrimidinone and
corresponding dihydropyrimidinethiones (DHPMs) has been known for more than a century …
corresponding dihydropyrimidinethiones (DHPMs) has been known for more than a century …
Synthesis, cytotoxicity, and COMPARE analysis of ferrocene and [3] ferrocenophane tetrasubstituted olefin derivatives against human cancer cells
Herein we report the antiproliferative effects of a series of 28 compounds against the MDA‐
MB‐231 breast cancer cell line, including the synthesis of seven new [3] ferrocenophanyl …
MB‐231 breast cancer cell line, including the synthesis of seven new [3] ferrocenophanyl …
N, N′-Dichlorobis (2, 4, 6-trichlorophenyl) urea (CC-2) as a new reagent for the synthesis of pyrimidone and pyrimidine derivatives via Biginelli reaction
A simple and efficient method for the synthesis of 3, 4-dihydropyrimidin-2-(1H) one and
benzo [4, 5] imidazo/thioazo [1, 2-a] pyrimidine derivatives has been described using N, N …
benzo [4, 5] imidazo/thioazo [1, 2-a] pyrimidine derivatives has been described using N, N …
Recent developments in the reactivity of the Biginelli compounds
The synthesis of highly functionalized molecules using multicomponent reactions became
increasingly important in organic and medicinal chemistry. The Biginelli reaction is a …
increasingly important in organic and medicinal chemistry. The Biginelli reaction is a …
Biginelli condensation: synthesis and structure diversification of 3, 4-dihydropyrimidin-2 (1H)-one derivatives
The realization of therapeutic potential of 3, 4-dihydropyrimidin-2 (1H)-ones (DHPMs) and
their structural as well as receptor bound conformational similarity with potent cardiovascular …
their structural as well as receptor bound conformational similarity with potent cardiovascular …
Solvent free synthesis of ferrocene based rhodamine–hydrazone molecular probe with improved bioaccumulation for sensing and imaging applications
Functionalization of ferrocenyl hydrazone with rhodamine based tag using solid state
synthetic method led to the formation of molecules containing both, fluorescent active and …
synthetic method led to the formation of molecules containing both, fluorescent active and …
Synthesis of pyrido-and pyrimido-fused heterocycles by multi-component reactions (part 3)
A HM Elwahy, MR Shaaban - Current Organic Synthesis, 2014 - ingentaconnect.com
Heterocycles constitute the largest diversity of organic molecules of chemical, biomedical,
and industrial significance. They widely exist in numerous natural products, such as …
and industrial significance. They widely exist in numerous natural products, such as …
Cu–EDTA-modified APTMS-Fe 3 O 4@ SiO 2 core–shell nanocatalyst: a novel magnetic recoverable catalyst for the Biginelli reaction
M Sheykhan, A Yahyazadeh, Z Rahemizadeh - RSC Advances, 2016 - pubs.rsc.org
A novel copper–ethylenediamine tetracarboxylate modified core–shell magnetic catalyst is
introduced. The prepared catalyst was fully characterized by various spectroscopic analyses …
introduced. The prepared catalyst was fully characterized by various spectroscopic analyses …
Unsymmetrically bi-functionalized 1, 1′-ferrocenyl bi-hydrazone and hydrazone-cyanovinyl molecules as fluorescent “on–off” sensor: Synthesis, cytotoxicity and …
S Dewangan, A Mishra, B Halder, A Mishra… - Inorganica Chimica …, 2023 - Elsevier
Unsymmetrically bi-functionalized ferrocenyl compounds are significant class of
multifunctional molecule having unique structural features, varied conformational …
multifunctional molecule having unique structural features, varied conformational …