Biginelli Reaction: A Multi-Component Type of Reaction and Synthetic Advancement in the Synthesis of Bioactive Dihydropyrimidinone Derivatives

R Ambatwar, V Gupta, S Kumar… - Mini-Reviews in Organic …, 2024 - benthamdirect.com
Background: In synthetic and medicinal chemistry, multi-component reactions (MCRs) are
considered an essential tool in synthesizing bioactive heterocyclic scaffolds. These …

Synthesis of dihydropyrimidinones and thiones by multicomponent reactions: strategies beyond the classical Biginelli reaction

JP Wan, Y Liu - Synthesis, 2010 - thieme-connect.com
The three-component Biginelli reaction for the synthesis of dihydropyrimidinone and
corresponding dihydropyrimidinethiones (DHPMs) has been known for more than a century …

Synthesis, cytotoxicity, and COMPARE analysis of ferrocene and [3] ferrocenophane tetrasubstituted olefin derivatives against human cancer cells

M Goermen, P Pigeon, S Top, EA Hillard… - …, 2010 - Wiley Online Library
Herein we report the antiproliferative effects of a series of 28 compounds against the MDA‐
MB‐231 breast cancer cell line, including the synthesis of seven new [3] ferrocenophanyl …

Recent developments in the reactivity of the Biginelli compounds

M Matache, C Dobrota, N D. Bogdan… - Current Organic …, 2011 - benthamdirect.com
The synthesis of highly functionalized molecules using multicomponent reactions became
increasingly important in organic and medicinal chemistry. The Biginelli reaction is a …

Biginelli condensation: synthesis and structure diversification of 3, 4-dihydropyrimidin-2 (1H)-one derivatives

K Singh, K Singh - Advances in heterocyclic chemistry, 2012 - Elsevier
The realization of therapeutic potential of 3, 4-dihydropyrimidin-2 (1H)-ones (DHPMs) and
their structural as well as receptor bound conformational similarity with potent cardiovascular …

Synthesis of pyrido-and pyrimido-fused heterocycles by multi-component reactions (part 3)

A HM Elwahy, MR Shaaban - Current Organic Synthesis, 2014 - ingentaconnect.com
Heterocycles constitute the largest diversity of organic molecules of chemical, biomedical,
and industrial significance. They widely exist in numerous natural products, such as …

Cu–EDTA-modified APTMS-Fe 3 O 4@ SiO 2 core–shell nanocatalyst: a novel magnetic recoverable catalyst for the Biginelli reaction

M Sheykhan, A Yahyazadeh, Z Rahemizadeh - RSC Advances, 2016 - pubs.rsc.org
A novel copper–ethylenediamine tetracarboxylate modified core–shell magnetic catalyst is
introduced. The prepared catalyst was fully characterized by various spectroscopic analyses …

Unsymmetrically bi-functionalized 1, 1′-ferrocenyl bi-hydrazone and hydrazone-cyanovinyl molecules as fluorescent “on–off” sensor: Synthesis, cytotoxicity and …

S Dewangan, A Mishra, B Halder, A Mishra… - Inorganica Chimica …, 2023 - Elsevier
Unsymmetrically bi-functionalized ferrocenyl compounds are significant class of
multifunctional molecule having unique structural features, varied conformational …