Malaria caused by Plasmodium is still a serious public health problem. Genomic editing is
essential to understand parasite biology, elucidate mechanical pathways, uncover gene …

The∼ 30 Mb genomes of the Plasmodium parasites that cause malaria each encode∼
5000 genes, but the functions of the majority remain unknown. This is due to a paucity of …

Malaria as vector-borne disease remains important health concern with over 200 million
cases globally. Novel antimalarial medicines and more effective vaccines must be …

The global spread of drug resistance is a major obstacle to the treatment of Plasmodium
falciparum malaria. The identification of drug-resistance genes is an essential step toward …

In the age of big data an important question is how to ensure we make the most out of the
resources we generate. In this review, we discuss the major methods used in Apicomplexan …

The emergence and spread of drug-resistant Plasmodium falciparum have compromised
antimalarial efficacy and threatened the global malaria elimination campaign using …

Genes associated with drug resistance of first line drugs for Plasmodium falciparum have
been identified and characterized of which three genes most commonly associated with …

The CRISPR mechanism, discovered in bacteria and archaea, operates as an adaptative
immune system at the genetic level. By using repetitive sequences, spacers derived from …

To discriminate between our own cells and foreign cells such as a pathogen, natural killer
cells are armed with inhibitory and activating immune receptors. In some cases, such as the …

Many Plasmodium genes remain uncharacterised due to low genetic tractability. Previous
large scale knockout screens have only been able to target about half of the genome in the …