The role of tumor microenvironment cells in colorectal cancer (CRC) cachexia

A Kasprzak - International journal of molecular sciences, 2021 - mdpi.com
Cancer cachexia (CC) is a multifactorial syndrome in patients with advanced cancer
characterized by weight loss via skeletal-muscle and adipose-tissue atrophy, catabolic …

Immunomodulatory activity of VEGF in cancer

A Lapeyre-Prost, M Terme, S Pernot, AL Pointet… - International review of …, 2017 - Elsevier
The ability of tumor cells to escape tumor immunosurveillance contributes to cancer
development. Factors produced in the tumor microenvironment create “tolerizing” conditions …

Expression of vascular endothelial growth factor in ovarian cancer inhibits tumor immunity through the accumulation of myeloid-derived suppressor cells

N Horikawa, K Abiko, N Matsumura, J Hamanishi… - Clinical Cancer …, 2017 - AACR
Purpose: High VEGF expression in ovarian cancer is an unfavorable prognostic factor.
However, the role of VEGF in tumor immunity remains unclear. Here, we examined the …

Immunomodulatory roles of VEGF pathway inhibitors in renal cell carcinoma

L Hirsch, R Flippot, B Escudier, L Albiges - Drugs, 2020 - Springer
Immune checkpoint inhibitors (ICIs) in combination with vascular endothelial growth factor
receptor (VEGFR) tyrosine kinase inhibitors (TKIs) have become a new standard of care in …

[HTML][HTML] Radiotherapy and cGAS/STING signaling: impact on MDSCs in the tumor microenvironment

VM Kho, VE Mekers, PN Span, J Bussink, GJ Adema - Cellular immunology, 2021 - Elsevier
Myeloid derived suppressor cells (MDSCs) are a highly heterogeneous population of
immature immune cells with immunosuppressive functions that are recruited to the tumor …

Targeting myeloid-derived suppressor cells and programmed death ligand 1 confers therapeutic advantage of ablative hypofractionated radiation therapy compared …

J Lan, R Li, LM Yin, L Deng, J Gui, BQ Chen… - International Journal of …, 2018 - Elsevier
Purpose Ablative hypofractionated radiation therapy (AHFRT) presents a therapeutic
advantage compared with conventional fractionated radiation therapy (CFRT) for primary …

The controlling nutritional status score serves as a predictor of short-and long-term outcomes for patients with stage 2 or 3 gastric cancer: analysis of a multi …

S Ryo, M Kanda, S Ito, Y Mochizuki, H Teramoto… - Annals of surgical …, 2019 - Springer
Background This study aimed to evaluate the predictive value of the preoperative
Controlling Nutritional Status (CONUT) score, which comprehensively reflects protein and …

A CMOS VEGF sensor for cancer diagnosis using a peptide aptamer-based functionalized microneedle

S Song, J Na, MH Jang, H Lee, HS Lee… - IEEE transactions on …, 2019 - ieeexplore.ieee.org
This paper presents the first CMOS Vascular Endothelial Growth Factor (VEGF) sensor for
cancer diagnosis directly from human blood. The sensor incorporates a peptide aptamer …

Cycloamylose‐nanogel drug delivery system‐mediated intratumor silencing of the vascular endothelial growth factor regulates neovascularization in tumor …

H Fujii, M Shin‐Ya, S Takeda, Y Hashimoto… - Cancer …, 2014 - Wiley Online Library
RNA i enables potent and specific gene silencing, potentially offering useful means for
treatment of cancers. However, safe and efficient drug delivery systems (DDS) that are …

Elevated neutrophil‑to‑lymphocyte ratio is associated with nutritional impairment, immune suppression, resistance to S‑1 plus cisplatin, and poor prognosis in patients …

K Gonda, M Shibata, Y Sato… - Molecular and …, 2017 - spandidos-publications.com
Gastric cancer continues to be a major cause of morbidity and mortality worldwide. Recently,
there has been a growing interest in the host inflammatory response and there is increasing …