Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …

Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …

Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere
shortening, an inevitable process due to successive cell divisions. In most tumour cells …

The most important prognostic factor for atherosclerotic cardiovascular disease is age,
independent of all other recognized risk factors. Recently, exome sequence analyses …

Clonal hematopoiesis is a common, age-related process in which a somatically mutated
hematopoietic precursor gives rise to a genetically distinct subpopulation in the blood. This …

Telomere length measured in leukocyte (LTL) has been found to be associated with the risk
of develo** several cancer types, including myeloproliferative neoplasms (MPNs). LTL is …

Myelofibrosis is a rare myeloproliferative neoplasm (MPN) with high risk for progression to
acute myeloid leukemia. Our integrated genomic analysis of up to 933 myelofibrosis cases …

Polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF)
are classical myeloproliferative neoplasms (MPN), characterized by specific somatic …

Abnormal telomerase activity plays a key role in the development of carcinogenesis. The
variants rs2736100 and rs2736098 of the telomerase reverse transcriptase (TERT) gene …

The risk of develo** a solid cancer is a major issue arising in the disease course of a
myeloproliferative neoplasm (MPN). Although the connection between the two diseases has …