Microcarriers for upscaling cultured meat production

V Bodiou, P Moutsatsou, MJ Post - Frontiers in nutrition, 2020 - frontiersin.org
Due to the considerable environmental impact and the controversial animal welfare
associated with industrial meat production, combined with the ever-increasing global …

Manufacturing human mesenchymal stem cells at clinical scale: process and regulatory challenges

V Jossen, C van den Bos, R Eibl, D Eibl - Applied microbiology and …, 2018 - Springer
Human mesenchymal stem cell (hMSC)-based therapies are of increasing interest in the
field of regenerative medicine. As economic considerations have shown, allogeneic therapy …

Cellular agriculture: opportunities and challenges

R Eibl, Y Senn, G Gubser, V Jossen… - Annual Review of …, 2021 - annualreviews.org
Cellular agriculture is the controlled and sustainable manufacture of agricultural products
with cells and tissues without plant or animal involvement. Today, microorganisms cultivated …

Mesenchymal stem cells as a cornerstone in a galaxy of intercellular signals: basis for a new era of medicine

S Fernández-Francos, N Eiro, LA Costa… - International journal of …, 2021 - mdpi.com
Around 40% of the population will suffer at some point in their life a disease involving tissue
loss or an inflammatory or autoimmune process that cannot be satisfactorily controlled with …

Influence of microenvironment on mesenchymal stem cell therapeutic potency: from planar culture to microcarriers

AC Tsai, R Jeske, X Chen, X Yuan, Y Li - Frontiers in bioengineering …, 2020 - frontiersin.org
Human mesenchymal stem cells (hMSCs) are a promising candidate in cell therapy as they
exhibit multilineage differentiation, homing to the site of injury, and secretion of trophic …

Expansion of human mesenchymal stem/stromal cells (hMSCs) in bioreactors using microcarriers: lessons learnt and what the future holds

PS Couto, MC Rotondi, A Bersenev, CJ Hewitt… - Biotechnology …, 2020 - Elsevier
Human mesenchymal stem/stromal cells (hMSCs) present a key therapeutic cellular
intervention for use in cell and gene therapy (CGT) applications due to their …

Recent advances in the use of microcarriers for cell cultures and their ex vivo and in vivo applications

XY Chen, JY Chen, XM Tong, JG Mei, YF Chen… - Biotechnology …, 2020 - Springer
Abstract Microcarriers are 100-to 300-micron support matrices that permit the growth of
adherent cells in bioreactor systems. They have a larger surface area to volume ratio in …

Bioengineering outlook on cultivated meat production

I Pajčin, T Knežić, I Savic Azoulay, V Vlajkov… - Micromachines, 2022 - mdpi.com
Cultured meat (also referred to as cultivated meat or cell-based meat)—CM—is fabricated
through the process of cellular agriculture (CA), which entails application of bioengineering …

Expansion of bovine skeletal muscle stem cells from spinner flasks to benchtop stirred-tank bioreactors for up to 38 days

D Tzimorotas, NT Solberg, RC Andreassen… - Frontiers in …, 2023 - frontiersin.org
Introduction Successful long-term expansion of skeletal muscle satellite cells (MuSCs) on a
large scale is fundamental for cultivating animal cells for protein production. Prerequisites for …

Biological considerations in scaling up therapeutic cell manufacturing

DS Cherian, T Bhuvan, L Meagher… - Frontiers in …, 2020 - frontiersin.org
Cell therapeutics—using cells as living drugs—have made advances in many areas of
medicine. One of the most clinically studied cell-based therapy products is mesenchymal …