Animal models of preeclampsia: causes, consequences, and interventions

KL Gatford, PH Andraweera, CT Roberts, AS Care - Hypertension, 2020‏ - ahajournals.org
Preeclampsia is a common pregnancy complication, affecting 2% to 8% of pregnancies
worldwide, and is an important cause of both maternal and fetal morbidity and mortality …

Preeclampsia: linking placental ischemia with maternal endothelial and vascular dysfunction

BA Bakrania, FT Spradley… - Comprehensive …, 2020‏ - pmc.ncbi.nlm.nih.gov
Preeclampsia (PE), a hypertensive disorder, occurs in 3% to 8% of pregnancies in the
United States and affects over 200,000 women and newborns per year. The United States …

Animal models of preeclampsia: investigating pathophysiology and therapeutic targets

BA Bakrania, EM George, JP Granger - American Journal of Obstetrics and …, 2022‏ - Elsevier
Animal models have been critical in investigating the pathogenesis, mediators, and even
therapeutic options for a number of diseases, including preeclampsia. Preeclampsia is the …

Maternal microbiome in preeclampsia pathophysiology and implications on offspring health

JA Ishimwe - Physiological reports, 2021‏ - Wiley Online Library
Preeclampsia is a devastating hypertensive pregnancy disorder that currently affects 2%–
8% of pregnancies worldwide. It is associated with maternal and fetal mortality and morbidity …

Cardiovascular dysfunction in intrauterine growth restriction

N Amruta, HK Kandikattu, S Intapad - Current Hypertension Reports, 2022‏ - Springer
Abstract Purpose of Review We highlight important new findings on cardiovascular
dysfunction in intrauterine growth restriction. Recent Findings Intrauterine growth restriction …

[HTML][HTML] Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations

FR De Bie, D Basurto, S Kumar, J Deprest… - International journal of …, 2022‏ - mdpi.com
Sildenafil, a phosphodiesterase 5 inhibitor with a vasodilatory and anti-remodeling effect,
has been investigated concerning various conditions during pregnancy. Per indication, we …

Prenatal interventions for fetal growth restriction in animal models: A systematic review

I Valenzuela, M Kinoshita, J van der Merwe, K Maršál… - Placenta, 2022‏ - Elsevier
Fetal growth restriction (FGR) in human pregnancy is associated with perinatal mortality,
short-and long-term morbidities. No prenatal therapy is currently established despite …

The role of sildenafil in treating brain injuries in adults and neonates

Y **ong, P Wintermark - Frontiers in Cellular Neuroscience, 2022‏ - frontiersin.org
Sildenafil is a recognized treatment for patients suffering from erectile dysfunction and
pulmonary hypertension. However, new evidence suggests that it may have a …

l‐Citrulline ameliorates pathophysiology in a rat model of superimposed preeclampsia

AWC Man, Y Zhou, UDP Lam… - British Journal of …, 2022‏ - Wiley Online Library
Background and Purpose Preeclampsia, characterized by hypertension, proteinuria and
restriction of fetal growth, is one of the leading causes of maternal and perinatal mortality. So …

Dietary supplements and vascular function in hypertensive disorders of pregnancy

AWC Man, Y Zhou, N **a, H Li - Pflügers Archiv-European Journal of …, 2023‏ - Springer
Hypertensive disorders of pregnancy are complications that can lead to maternal and infant
mortality and morbidity. Hypertensive disorders of pregnancy are generally defined as …