Soft connective tissues at steady state are dynamic; resident cells continually read
environmental cues and respond to them to promote homeostasis, including maintenance of …

This review article focuses on the physiochemical mechanisms underlying nanoparticle
uptake into cells. When nanoparticles are in close vicinity to a cell, the interactions between …

INTRODUCTION Human beings are equipped with multiple senses (sight, hearing, smell,
taste, touch, and proprioception) to help them to react properly to their environment. The …

Microenvironments appear important in stem cell lineage specification but can be difficult to
adequately characterize or control with soft tissues. Naive mesenchymal stem cells (MSCs) …

Tumors are stiffer than normal tissue, and tumors have altered integrins. Because integrins
are mechanotransducers that regulate cell fate, we asked whether tissue stiffness could …

Recent progress in the design and application of artificial cellular microenvironments and
nanoenvironments has revealed the extraordinary ability of cells to adjust their cytoskeletal …

The shapes of eukaryotic cells and ultimately the organisms that they form are defined by
cycles of mechanosensing, mechanotransduction and mechanoresponse. Local sensing of …

Cell adhesions to the extracellular matrix (ECM) are necessary for morphogenesis, immunity
and wound healing,. Focal adhesions are multifunctional organelles that mediate cell–ECM …

Mechanical forces are central to developmental, physiological and pathological processes.
However, limited understanding of force transmission within sub-cellular structures is a …

At present, the prime methodology for studying neuronal circuit-connectivity, physiology and
pathology under in vitro or in vivo conditions is by using substrate-integrated microelectrode …