Multifaceted role of neuropilins in the immune system: potential targets for immunotherapy

S Roy, AK Bag, RK Singh, JE Talmadge… - Frontiers in …, 2017 - frontiersin.org
Neuropilins (NRPs) are non-tyrosine kinase cell surface glycoproteins expressed in all
vertebrates and widely conserved across species. The two isoforms, such as neuropilin-1 …

[HTML][HTML] Progress in delivery of siRNA-based therapeutics employing nano-vehicles for treatment of prostate cancer

M Ashrafizadeh, K Hushmandi, E Rahmani Moghadam… - Bioengineering, 2020 - mdpi.com
Prostate cancer (PCa) accounts for a high number of deaths in males with no available
curative treatments. Patients with PCa are commonly diagnosed in advanced stages due to …

Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

ZD Nassar, CY Mah, J Dehairs, IJG Burvenich, S Irani… - Elife, 2020 - elifesciences.org
Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer
(PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic …

NRP1 promotes prostate cancer progression via modulating EGFR-dependent AKT pathway activation

P Zhang, L Chen, F Zhou, Z He, G Wang, Y Luo - Cell death & disease, 2023 - nature.com
Prostate cancer (PCa) is the most common malignant tumor with a high global incidence in
males. The mechanism underlying PCa progression is still not clear. This study observed …

MicroRNAs in cancer metastasis and angiogenesis

W Lou, J Liu, Y Gao, G Zhong, D Chen, J Shen… - …, 2017 - pmc.ncbi.nlm.nih.gov
Cancer metastasis is a malignant process by which tumor cells migrate from their primary
site of origin to other organs. It is the main cause of poor prognosis in cancer patients …

Neuropilins in the context of tumor vasculature

S Niland, JA Eble - International journal of molecular sciences, 2019 - mdpi.com
Neuropilin-1 and Neuropilin-2 form a small family of plasma membrane spanning receptors
originally identified by the binding of semaphorin and vascular endothelial growth factor …

Prostate cancer genetic risk and associated aggressive disease in men of African ancestry

PXY Soh, N Mmekwa, DC Petersen, K Gheybi… - Nature …, 2023 - nature.com
African ancestry is a significant risk factor for prostate cancer and advanced disease. Yet,
genetic studies have largely been conducted outside the context of Sub-Saharan Africa …

[HTML][HTML] The nervous system development regulator neuropilin-1 as a potential prognostic marker and therapeutic target in brain cancer

EM Rodrigues, AF Giovanini, CAPM Ribas, O Malafaia… - Cancers, 2023 - mdpi.com
Simple Summary Dysregulation of molecular mechanisms that regulate nervous system
development may be at the origin of brain tumors. We reviewed the role of neuropilin-1 …

Myeloid checkpoints for cancer immunotherapy

Y Qian, T Yang, H Liang… - Chinese Journal of Cancer …, 2022 - pmc.ncbi.nlm.nih.gov
Myeloid checkpoints are receptors on the myeloid cell surface which can mediate inhibitory
signals to modulate anti-tumor immune activities. They can either inhibit cellular …

Novel histopathological biomarkers in prostate cancer: implications and perspectives

P Kiełb, K Kowalczyk, A Gurwin, Ł Nowak, W Krajewski… - Biomedicines, 2023 - mdpi.com
Prostate cancer (PCa) is the second most frequently diagnosed cancer in men. Despite the
significant progress in cancer diagnosis and treatment over the last few years, the approach …