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Multifaceted role of neuropilins in the immune system: potential targets for immunotherapy
Neuropilins (NRPs) are non-tyrosine kinase cell surface glycoproteins expressed in all
vertebrates and widely conserved across species. The two isoforms, such as neuropilin-1 …
vertebrates and widely conserved across species. The two isoforms, such as neuropilin-1 …
[HTML][HTML] Progress in delivery of siRNA-based therapeutics employing nano-vehicles for treatment of prostate cancer
Prostate cancer (PCa) accounts for a high number of deaths in males with no available
curative treatments. Patients with PCa are commonly diagnosed in advanced stages due to …
curative treatments. Patients with PCa are commonly diagnosed in advanced stages due to …
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis
Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer
(PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic …
(PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic …
NRP1 promotes prostate cancer progression via modulating EGFR-dependent AKT pathway activation
P Zhang, L Chen, F Zhou, Z He, G Wang, Y Luo - Cell death & disease, 2023 - nature.com
Prostate cancer (PCa) is the most common malignant tumor with a high global incidence in
males. The mechanism underlying PCa progression is still not clear. This study observed …
males. The mechanism underlying PCa progression is still not clear. This study observed …
MicroRNAs in cancer metastasis and angiogenesis
W Lou, J Liu, Y Gao, G Zhong, D Chen, J Shen… - …, 2017 - pmc.ncbi.nlm.nih.gov
Cancer metastasis is a malignant process by which tumor cells migrate from their primary
site of origin to other organs. It is the main cause of poor prognosis in cancer patients …
site of origin to other organs. It is the main cause of poor prognosis in cancer patients …
Neuropilins in the context of tumor vasculature
S Niland, JA Eble - International journal of molecular sciences, 2019 - mdpi.com
Neuropilin-1 and Neuropilin-2 form a small family of plasma membrane spanning receptors
originally identified by the binding of semaphorin and vascular endothelial growth factor …
originally identified by the binding of semaphorin and vascular endothelial growth factor …
Prostate cancer genetic risk and associated aggressive disease in men of African ancestry
African ancestry is a significant risk factor for prostate cancer and advanced disease. Yet,
genetic studies have largely been conducted outside the context of Sub-Saharan Africa …
genetic studies have largely been conducted outside the context of Sub-Saharan Africa …
[HTML][HTML] The nervous system development regulator neuropilin-1 as a potential prognostic marker and therapeutic target in brain cancer
Simple Summary Dysregulation of molecular mechanisms that regulate nervous system
development may be at the origin of brain tumors. We reviewed the role of neuropilin-1 …
development may be at the origin of brain tumors. We reviewed the role of neuropilin-1 …
Myeloid checkpoints for cancer immunotherapy
Y Qian, T Yang, H Liang… - Chinese Journal of Cancer …, 2022 - pmc.ncbi.nlm.nih.gov
Myeloid checkpoints are receptors on the myeloid cell surface which can mediate inhibitory
signals to modulate anti-tumor immune activities. They can either inhibit cellular …
signals to modulate anti-tumor immune activities. They can either inhibit cellular …
Novel histopathological biomarkers in prostate cancer: implications and perspectives
P Kiełb, K Kowalczyk, A Gurwin, Ł Nowak, W Krajewski… - Biomedicines, 2023 - mdpi.com
Prostate cancer (PCa) is the second most frequently diagnosed cancer in men. Despite the
significant progress in cancer diagnosis and treatment over the last few years, the approach …
significant progress in cancer diagnosis and treatment over the last few years, the approach …