Anhedonia, or markedly diminished interest or pleasure, is a hallmark symptom of major
depression, schizophrenia and other neuropsychiatric disorders. Over the past three …

Objective: Functional neuroimaging investigations of major depressive disorder can
advance both the neural theory and treatment of this debilitating illness. Inconsistency of …

Functional significance of delta oscillations is not fully understood. One way to approach this
question would be from an evolutionary perspective. Delta oscillations dominate the EEG of …

Context Although differences in clinical characteristics exist between major depressive
disorder (MDD) and bipolar disorder (BD), consistent structural brain abnormalities that …

This review begins with a brief historical overview of attempts in the first half of the 20th
century to discern brain systems that underlie emotion and emotional behavior. These early …

This review of major depressive disorder is a comprehensive account of the genetic,
biochemical, and neurophysiological changes that have been implicated in the disorder. No …

Thalamocortical dysrhythmia (TCD) is a model proposed to explain divergent neurological
disorders. It is characterized by a common oscillatory pattern in which resting-state alpha …

All available antidepressant medications are based on serendipitous discoveries of the
clinical efficacy of two classes of antidepressants more than 50 years ago. These tricyclic …

The anterior cingulate cortex (ACC) ventral to the genu of the corpus callosum has been
implicated in the modulation of emotional behavior on the basis of neuroimaging studies in …

primate research suggests that affiliation is a highly complex construct. studies of primate
affiliation demonstrate the need to distinguish between various affiliative behaviors, consider …