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A TGFβ-ECM-integrin signaling axis drives structural reconfiguration of the bile duct to promote polycystic liver disease
The formation of multiple cysts in the liver occurs in a number of isolated monogenic
diseases or multisystemic syndromes, during which bile ducts develop into fluid-filled biliary …
diseases or multisystemic syndromes, during which bile ducts develop into fluid-filled biliary …
[HTML][HTML] Chrysin and Capsaicin induces premature senescence and apoptosis via mitochondrial dysfunction and p53 elevation in Cervical cancer cells
Current studies are focusing on the anti-cancerous properties of natural bioactive
compounds, primarily those included in the human diet. These compounds have the …
compounds, primarily those included in the human diet. These compounds have the …
[HTML][HTML] Three-Dimensional Models: Biomimetic Tools That Recapitulate Breast Tissue Architecture and Microenvironment to Study Ductal Carcinoma In Situ …
Diagnosis of ductal carcinoma in situ (DCIS) presents a challenge as we cannot yet
distinguish between those lesions that remain dormant from cases that may progress to …
distinguish between those lesions that remain dormant from cases that may progress to …
Development of bioengineered 3D patient derived breast cancer organoid model focusing dynamic fibroblast–stem cell reciprocity
NS Roy, M Kumari, K Alam… - Progress in …, 2024 - iopscience.iop.org
Abstract Three-dimensional (3D) models, such as tumor spheroids and organoids, are
increasingly developed by integrating tissue engineering, regenerative medicine, and …
increasingly developed by integrating tissue engineering, regenerative medicine, and …
JNJ-64619178 radiosensitizes and suppresses fractionated ionizing radiation-induced neuroendocrine differentiation (NED) in prostate cancer
Background Radiation therapy (RT) is a standard treatment regimen for locally advanced
prostate cancer; however, its failure results in tumor recurrence, metastasis, and cancer …
prostate cancer; however, its failure results in tumor recurrence, metastasis, and cancer …
Differential regulation of fibronectin expression and fibrillogenesis by autocrine TGF-β1 signaling in malignant and benign mammary epithelial cells
MM Sofroniou, CA Lemmon - The International Journal of Biochemistry & …, 2023 - Elsevier
Remodeling of the extracellular matrix (ECM) is a key hallmark of cancer progression. A
critical component of ECM remodeling is the assembly of the glycoprotein fibronectin (FN) …
critical component of ECM remodeling is the assembly of the glycoprotein fibronectin (FN) …
Primary cilia loss promotes reactivation of morphogenesis and cyst-fission through a deregulated TGFβ-ECM-Integrin axis in polycystic liver disease
Pathological liver cysts are an important comorbidity in multiple diseases and syndromes (,)
driven by dysfunction of the primary cilium (PC), a complex sensory organelle that protrudes …
driven by dysfunction of the primary cilium (PC), a complex sensory organelle that protrudes …
The Microenvironment in DCIS and Its Role in Disease Progression
MR Roozitalab, N Prekete, M Allen, RP Grose… - A Guide to Breast …, 2025 - Springer
Ductal carcinoma in situ (DCIS) accounts for~ 20% of all breast cancer diagnoses but whilst
known to be a precursor of invasive breast cancer (IBC), evidence suggests only one in six …
known to be a precursor of invasive breast cancer (IBC), evidence suggests only one in six …