Cancer stem cells: advances in knowledge and implications for cancer therapy

X Chu, W Tian, J Ning, G **ao, Y Zhou… - … and Targeted Therapy, 2024 - nature.com
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia

AGX Zeng, S Bansal, L **, A Mitchell, WC Chen… - Nature medicine, 2022 - nature.com
The treatment landscape of acute myeloid leukemia (AML) is evolving, with promising
therapies entering clinical translation, yet patient responses remain heterogeneous, and …

Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

G Gunaydin, ME Gedik, S Ayan - Frontiers in chemistry, 2021 - frontiersin.org
Photodynamic therapy (PDT) has been used as an anti-tumor treatment method for a long
time and photosensitizers (PS) can be used in various types of tumors. Originally, light is an …

Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents

HM Zhou, JG Zhang, X Zhang, Q Li - Signal transduction and targeted …, 2021 - nature.com
Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation

YH Cho, EJ Ro, JS Yoon, T Mizutani, DW Kang… - Nature …, 2020 - nature.com
Fluorouracil (5-FU) remains the first-line treatment for colorectal cancer (CRC). Although 5-
FU initially de-bulks the tumor mass, recurrence after chemotherapy is the barrier to effective …

Ice inhibition for cryopreservation: materials, strategies, and challenges

T Chang, G Zhao - Advanced Science, 2021 - Wiley Online Library
Cryopreservation technology has developed into a fundamental and important supporting
method for biomedical applications such as cell‐based therapeutics, tissue engineering …

[HTML][HTML] Machine learning identifies stemness features associated with oncogenic dedifferentiation

TM Malta, A Sokolov, AJ Gentles, T Burzykowski… - Cell, 2018 - cell.com
Cancer progression involves the gradual loss of a differentiated phenotype and acquisition
of progenitor and stem-cell-like features. Here, we provide novel stemness indices for …

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

DA Pollyea, BM Stevens, CL Jones, A Winters, S Pei… - Nature medicine, 2018 - nature.com
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. Leukemia
stem cells (LSCs) drive the initiation and perpetuation of AML, are quantifiably associated …

[HTML][HTML] Leukemic stem cells and therapy resistance in acute myeloid leukemia

P Stelmach, A Trumpp - Haematologica, 2023 - ncbi.nlm.nih.gov
A major obstacle in the treatment of acute myeloid leukemia (AML) is refractory disease or
relapse after achieving remission. The latter arises from a few therapy-resistant cells within …