Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Mechanisms of protein homeostasis are crucial for overseeing the clearance of misfolded
and toxic proteins over the lifetime of an organism, thereby ensuring the health of neurons …

Expansions of a hexanucleotide repeat (GGGGCC) in the noncoding region of the C9orf72
gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and …

Amyotrophic Lateral Sclerosis | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Access provided by Oregon Health & Science …

Approximately 70 human RNA-binding proteins (RBPs) contain a prion-like domain (PrLD).
PrLDs are low-complexity domains that possess a similar amino acid composition to prion …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
involving loss of upper and lower motor neurons, with most cases ending in death within 3–5 …

Neuroinflammation is a common feature in neurodegenerative diseases and strategies to
modulate neuroinflammatory processes are increasingly considered as therapeutic options …

Brain function critically relies on blood vessels to supply oxygen and nutrients, to establish a
barrier for neurotoxic substances, and to clear waste products. The archetypal vascular …

Hexanucleotide repeat expansion in the C9orf72 gene is a leading cause of frontotemporal
lobar degeneration (FTLD) with amyotrophic lateral sclerosis (ALS). Reduced expression of …

Amyotrophic lateral sclerosis (ALS) is a devastating, uniformly lethal degenerative disorder
of motor neurons that overlaps clinically with frontotemporal dementia (FTD). Investigations …