Urokinase-type plasminogen activator receptor (uPAR) is an attractive target for the
treatment of cancer, because it is expressed at low levels in healthy tissues but at high levels …

Urokinase-type plasminogen activator receptor (uPAR) expression is elevated during
inflammation and tissue remodelling and in many human cancers, in which it frequently …

The plasminogen system has been implicated in clot lysis, wound healing, tissue
regeneration, cancer and many other processes that affect health and disease. The …

Integrins are heterodimeric cell adhesion molecules that link the extracellular matrix to the
cytoskeleton. The integrin family in man comprises 24 members, which are the result of …

The matrix metalloproteinases (MMP)-2 and-9, also known as the gelatinases have been
long recognized as major contributors to the proteolytic degradation of extracellular matrix …

Urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycosyl-phosphatidyl-
inositol anchored (GPI) membrane protein. The uPAR primary ligand is the serine protease …

The use of cancer biomarkers to anticipate the outlines of disease has been an emerging
issue, especially as cancer treatment has made such positive steps in the last few years …

Simple Summary The uPA/uPAR system is highly involved in cancer progression and
metastasis. Many studies have definitively assessed that the high expression of urokinase …

The urokinase-type plasminogen activator (uPA), its inhibitor PA I-1 and its cellular receptor
(uPAR), play a pivotal role in pericellular proteolysis. In addition, through their interactions …

Caveolin-1 is an essential structural constituent of caveolae that has been implicated in
mitogenic signaling and oncogenesis. Caveolin-1 is down-regulated in oncogene …