The physiological process of biomineralization is complex and deviation from it leads to a
variety of diseases. Progress in the past 10 years has enhanced understanding of the …

Abstract In 2020, the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney
Disease (DAPA-CKD) trial first demonstrated that inhibition of the sodium–glucose …

Background The roles of asymptomatic hyperuricemia or uric acid (UA) crystals in CKD
progression are unknown. Hypotheses to explain links between UA deposition and …

Signaling pathways of regulated necrosis, such as necroptosis and ferroptosis, contribute to
acute kidney injury (AKI), but the role of pyroptosis is unclear. Pyroptosis is mediated by the …

Calcium oxalate (CaOx) stones are among the most common types of kidney stones and are
associated with renal tubular damage, interstitial fibrosis, and chronic kidney disease. The …

The present study aimed to evaluate the role and mechanism of ferrostatin‑1 (Fer‑1) in
oxalate (Ox)‑induced renal tubular epithelial cell injury, fibrosis, and calcium oxalate (CaOx) …

Intrarenal calcium oxalate (CaOx) crystals induce renal tubular epithelial cells (TECs) injury
and inflammation, which involve Toll-like receptor 4 (TLR4)/interferon regulatory factor 1 …

Inflammasome-driven release of interleukin (IL)-1β is a central element of many forms of
sterile inflammation and has been evident to promote the onset and progression of diabetic …

Kidney fibrosis is characterized by expansion and activation of platelet‐derived growth factor
receptor‐β (PDGFR‐β)‐positive mesenchymal cells. To study the consequences of PDGFR …

Although monosodium urate (MSU) crystals are known to trigger inflammation, published
data on soluble uric acid (sUA) in this context are discrepant. We hypothesized that diverse …