The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …

Cancer remains the leading cause of death worldwide despite advances in treatment
options for patients. As such, safe and effective therapeutics are required. Short peptides …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Owing to diverse abiotic stresses and global climate deterioration, the agricultural
production worldwide is suffering serious losses. Breeding stress-resilient crops with higher …

Apolipoprotein E4 (APOE4), the main susceptibility gene for Alzheimer's disease, leads to
blood–brain barrier (BBB) breakdown in humans and mice. Remarkably, BBB dysfunction …

Genome-scale metabolic models (GEMs) enable the mathematical simulation of the
metabolism of archaea, bacteria, and eukaryotic organisms. GEMs quantitatively define a …

Cancer is the second leading cause of death globally, trailing only heart disease. In the
United States alone, 1.9 million new cancer cases and 609,360 deaths were recorded for …

Modeling and analyses of complex systems using network theory have been an object of
study for a long time. They have caught attention in many disciplines such as sociology …

Complex protein networks are involved in nearly all cellular processes. To uncover these
vast networks of protein interactions, various high-throughput screening technologies have …

Abstract Background The Coronavirus disease 2019 pneumonia broke out in 2019 (COVID-
19) and spread rapidly, which causes serious harm to the health of people and a huge …