[HTML][HTML] Sphingosine 1-phosphate receptor, a new therapeutic direction in different diseases

H Chen, J Wang, C Zhang, P Ding, S Tian… - Biomedicine & …, 2022‏ - Elsevier
Abstract Sphingosine 1-phosphate receptor (S1PR), as a kind of G protein-coupled receptor,
has five subtypes, including S1PR1, S1PR2, S1PR3, S1PR4, and S1PR5. Sphingosine 1 …

Immune metabolism in TH2 responses: New opportunities to improve allergy treatment—Disease-Specific Findings (Part 1)

A Goretzki, J Zimmermann, H Rainer, YJ Lin… - Current Allergy and …, 2023‏ - Springer
Abstract Purpose of Review Recent high-level publications have shown an intricate
connection between immune effector function and the metabolic state of the respective cells …

First Insight into the Formation of In Vivo Transformation Products of 2-Ethylhexyl diphenyl phosphate in Zebrafish and Prediction of Their Potential Toxicities

R Yang, Y Ye, Y Chen, Y Yang, L Yang… - Environmental …, 2022‏ - ACS Publications
As a frequently detected organophosphorus flame retardant in the environment, 2-ethylhexyl
diphenyl phosphate (EHDPHP) is vulnerable to biotransformation, while the transformation …

Reversal of cholestatic liver disease by the inhibition of sphingosine 1-phosphate receptor 2 signaling

H Cao, L Chen, Z Zeng, X Wu, Y Lei, W Jia, G Yue, B Yi… - PeerJ, 2024‏ - peerj.com
Aims The objective of this study is to examine the impact of inhibiting Sphingosine 1-
phosphate receptor 2 (S1PR2) on liver inflammation, fibrogenesis, and changes of gut …

Functionalizing collagen membranes with MSC-conditioned media promotes guided bone regeneration in rat calvarial defects

S Shanbhag, C Kampleitner, N Al-Sharabi… - Cells, 2023‏ - mdpi.com
Functionalizing biomaterials with conditioned media (CM) from mesenchymal stromal cells
(MSC) is a promising strategy for enhancing the outcomes of guided bone regeneration …

[HTML][HTML] Potential metabolic biomarkers in adult asthmatics

S Sim, Y Choi, HS Park - Metabolites, 2021‏ - mdpi.com
Asthma is the most common chronic airway inflammation, with multiple phenotypes caused
by complicated interactions of genetic, epigenetic, and environmental factors. To date …

Antiatherogenic Effects of Quercetin in the THP-1 Macrophage Model In Vitro, With Insights Into Its Signaling Mechanisms Using In Silico Analysis

EA Huwait, SY Saddeek, RF Al-Massabi… - Frontiers in …, 2021‏ - frontiersin.org
Background: Atherosclerosis (AS), a major risk factor for stroke and brain tissue destruction,
is an inflammatory disease of the blood vessels, and the underlying pathology is …

The temporal transcriptomic signature of cartilage formation

R Takács, J Vágó, S Póliska, PN Pushparaj… - Nucleic Acids …, 2023‏ - academic.oup.com
Chondrogenesis is a multistep process, in which cartilage progenitor cells generate a tissue
with distinct structural and functional properties. Although several approaches to cartilage …

Novel insights into the whole-blood DNA methylome of asthma in ethnically diverse children and youth

E Herrera-Luis, C Rosa-Baez… - European …, 2023‏ - publications.ersnet.org
Background The epigenetic mechanisms of asthma remain largely understudied in African
Americans and Hispanics/Latinos, two populations disproportionately affected by asthma …