The Hippo signaling pathway is a highly conserved signaling network for controlling organ
size, tissue homeostasis, and regeneration. It integrates a wide range of intracellular and …

Liquid–liquid phase separation (LLPS), an emerging biophysical phenomenon, can
sequester molecules to implement physiological and pathological functions. LLPS …

Despite recent studies implicating liquid-like biomolecular condensates in diverse cellular
processes, many biomolecular condensates exist in a solid-like state, and their function and …

RAS GTPases bind effectors to convert upstream cues to changes in cellular function.
Effectors of classical H/K/NRAS are defined by RBD/RA domains which recognize the GTP …

Insect wing development is a fascinating and intricate process that involves the regulation of
wing size through cell proliferation and apoptosis. In this study, we find that Ter94, an AAA …

The Hippo pathway is a highly conserved signaling network integrating diverse intracellular,
intercellular and extracellular biological cues to regulate complex physiological processes …

Signal transduction enables cells to sense and respond to chemical and mechanical
information in the extracellular environment. Recently, phase separation has emerged as a …

Condensed droplets of protein regulate many cellular functions, yet the physiological
conditions regulating their formation remain largely unexplored. Increasing our …

Abstract Background Prolyl-4-hydroxylase-A2 (P4HA2) is a pivotal enzyme involved in the
regulation of tumorigenesis and progression. However, the precise biological roles and …

The WW and C2 domain-containing protein (WWC2) is implicated in several neurological
disorders. Here, we demonstrate that WWC2 interacts with inhibitory, but not excitatory …