Ceramides and other sphingolipids as drivers of cardiovascular disease

RH Choi, SM Tatum, JD Symons… - Nature Reviews …, 2021 - nature.com
Increases in calorie consumption and sedentary lifestyles are fuelling a global pandemic of
cardiometabolic diseases, including coronary artery disease, diabetes mellitus …

Ceramides in metabolism: key lipotoxic players

B Chaurasia, SA Summers - Annual review of physiology, 2021 - annualreviews.org
The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …

Effects of polystyrene microplastics on the composition of the microbiome and metabolism in larval zebrafish

Z Wan, C Wang, J Zhou, M Shen, X Wang, Z Fu, Y ** - Chemosphere, 2019 - Elsevier
Microplastics are major pollutants in marine environment and may have health effects on
aquatic organisms. In this study, we used two sizes (5 and 50 μm diameter) of fluorescent …

Cholesterol interactions with phospholipids in membranes

H Ohvo-Rekilä, B Ramstedt, P Leppimäki… - Progress in lipid …, 2002 - Elsevier
Mammalian cell membranes are composed of a complex array of glycerophospholipids and
sphingolipids that vary in head-group and acyl-chain composition. In a given cell type …

Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics

X Han, S Rozen, SH Boyle, C Hellegers, H Cheng… - PloS one, 2011 - journals.plos.org
Background The development of plasma biomarkers could facilitate early detection, risk
assessment and therapeutic monitoring in Alzheimer's disease (AD). Alterations in …

MALDI imaging of lipid biochemistry in tissues by mass spectrometry

KA Zemski Berry, JA Hankin, RM Barkley… - Chemical …, 2011 - ACS Publications
As a result of recent advances, remarkable images revealing the distribution of complex
lipids in tissues are now generated by matrix-assisted laser desorption/ionization imaging …

[PDF][PDF] Structure and origin of ordered lipid domains in biological membranes

DA Brown, E London - The Journal of membrane biology, 1998 - academia.edu
The clearest function of membrane lipids is to form amphipathic bilayers that surround cells
and organelles and block leakage of hydrophilic compounds while housing membrane …

Ceramides and skin function

L Coderch, O López, A de la Maza, JL Parra - American journal of clinical …, 2003 - Springer
Ceramides are the major lipid constituent of lamellar sheets present in the intercellular
spaces of the stratum corneum. These lamellar sheets are thought to provide the barrier …

Recombinant protein secretion in Escherichia coli

FJM Mergulhão, DK Summers, GA Monteiro - Biotechnology advances, 2005 - Elsevier
The secretory production of recombinant proteins by the Gram-negative bacterium
Escherichia coli has several advantages over intracellular production as inclusion bodies. In …

[HTML][HTML] Sphingolipids in food and the emerging importance of sphingolipids to nutrition

H Vesper, EM Schmelz, MN Nikolova-Karakashian… - The Journal of …, 1999 - Elsevier
Eukaryotic organisms as well as some prokaryotes and viruses contain sphingolipids, which
are defined by a common structural feature, ie, a “sphingoid base” backbone such as D …