The basal ganglia occupy the core of the forebrain and consist of evolutionarily conserved
motor nuclei that form recurrent circuits critical for motivation and motor planning. The …

The intrinsic electrical properties and the synaptic input-output relationships of neurons are
governed by the action of voltage-dependent ion channels. The localization of specific …

Principal medium spiny projection neurons (MSNs) of the striatum have long been thought to
be homogeneous in their somatodendritic morphology and physiology. Recent work using …

Substantia nigra dopamine neurons have been implicated in the initiation and invigoration
of movement, presumably through their modulation of striatal projection neuron (SPN) …

Long-term depression (LTD) of the synapse formed between cortical pyramidal neurons and
striatal medium spiny neurons is central to many theories of motor plasticity and associative …

It is often assumed that all neurons of the same cell type have identical intrinsic properties,
both within an animal and between animals. We exploited the large size and small number …

The intrinsic electrical properties of neurons are shaped in large part by the action of voltage-
gated ion channels. Molecular cloning studies have revealed a large family of ion channel …

The principal neurons of the striatum, GABAergic medium spiny neurons (MSNs), are
interconnected by local recurrent axon collateral synapses. Although critical to many striatal …

Shal-type (Kv4. x) K+ channels are expressed in a variety of tissue, with particularly high
levels in the brain and heart. These channels are the primary subunits that contribute to …

Subthreshold-activating somatodendritic A-type potassium channels have fundamental roles
in neuronal signaling and plasticity which depend on their unique cellular localization …