Copper dyshomeostasis in neurodegenerative diseases—therapeutic implications

G Gromadzka, B Tarnacka, A Flaga… - International journal of …, 2020 - mdpi.com
Copper is one of the most abundant basic transition metals in the human body. It takes part
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …

[HTML][HTML] Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer's disease: Limitations, and current and future perspectives

KD Fasae, AO Abolaji, TR Faloye, AY Odunsi… - Journal of Trace …, 2021 - Elsevier
Background Alzheimer's disease (AD) is the most prevalent cause of cognitive impairment
and dementia worldwide. The pathobiology of the disease has been studied in the form of …

Iron and chelation in biochemistry and medicine: new approaches to controlling iron metabolism and treating related diseases

GJ Kontoghiorghes, CN Kontoghiorghe - Cells, 2020 - mdpi.com
Iron is essential for all living organisms. Many iron-containing proteins and metabolic
pathways play a key role in almost all cellular and physiological functions. The diversity of …

Current biomedical use of copper chelation therapy

S Baldari, G Di Rocco, G Toietta - International journal of molecular …, 2020 - mdpi.com
Copper is an essential microelement that plays an important role in a wide variety of
biological processes. Copper concentration has to be finely regulated, as any imbalance in …

Redox interactions of vitamin C and iron: Inhibition of the pro-oxidant activity by deferiprone

VA Timoshnikov, TV Kobzeva, NE Polyakov… - International journal of …, 2020 - mdpi.com
Ascorbic acid (AscH2) is one of the most important vitamins found in the human diet, with
many biological functions including antioxidant, chelating, and coenzyme activities. Ascorbic …

Promising drug targets and associated therapeutic interventions in Parkinson's disease

SN Rai, P Singh, R Varshney… - Neural regeneration …, 2021 - journals.lww.com
Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the
availability of symptomatic treatments, response towards the health of PD patients remains …

Polyphenols as potential metal chelation compounds against Alzheimer's disease

J Lakey-Beitia, AM Burillo, G La Penna… - Journal of …, 2021 - content.iospress.com
Alzheimer's disease (AD) is the most common neurodegenerative disease affecting more
than 50 million people worldwide. The pathology of this multifactorial disease is primarily …

Influence of heavy metals in Parkinson's disease: an overview

B Vellingiri, A Suriyanarayanan, KS Abraham… - Journal of …, 2022 - Springer
Parkinson's disease (PD) is an ageing disorder with deterioration of dopamine neurons
which leads to motor complications like tremor, stiffness, slow movement and postural …

Metal incorporated sulfonamides as promising multidrug targets: Combined enzyme inhibitory, antimicrobial, antioxidant and theoretical exploration

SH Sumrra, AU Hassan, MN Zafar, SS Shafqat… - Journal of Molecular …, 2022 - Elsevier
In this report, new sulfonamide based ligands (L 1)-(L 3) from 4-amino-N-(pyrimidin-2-yl)
benzene-1-sulfonamide are synthesized and branded on the basis of their physical …

Trying to solve the puzzle of the interaction of ascorbic acid and iron: Redox, chelation and therapeutic implications

GJ Kontoghiorghes, A Kolnagou, CN Kontoghiorghe… - Medicines, 2020 - mdpi.com
Iron and ascorbic acid (vitamin C) are essential nutrients for the normal growth and
development of humans, and their deficiency can result in serious diseases. Their …