Copper dyshomeostasis in neurodegenerative diseases—therapeutic implications
G Gromadzka, B Tarnacka, A Flaga… - International journal of …, 2020 - mdpi.com
Copper is one of the most abundant basic transition metals in the human body. It takes part
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …
[HTML][HTML] Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer's disease: Limitations, and current and future perspectives
Background Alzheimer's disease (AD) is the most prevalent cause of cognitive impairment
and dementia worldwide. The pathobiology of the disease has been studied in the form of …
and dementia worldwide. The pathobiology of the disease has been studied in the form of …
Iron and chelation in biochemistry and medicine: new approaches to controlling iron metabolism and treating related diseases
GJ Kontoghiorghes, CN Kontoghiorghe - Cells, 2020 - mdpi.com
Iron is essential for all living organisms. Many iron-containing proteins and metabolic
pathways play a key role in almost all cellular and physiological functions. The diversity of …
pathways play a key role in almost all cellular and physiological functions. The diversity of …
Current biomedical use of copper chelation therapy
S Baldari, G Di Rocco, G Toietta - International journal of molecular …, 2020 - mdpi.com
Copper is an essential microelement that plays an important role in a wide variety of
biological processes. Copper concentration has to be finely regulated, as any imbalance in …
biological processes. Copper concentration has to be finely regulated, as any imbalance in …
Redox interactions of vitamin C and iron: Inhibition of the pro-oxidant activity by deferiprone
VA Timoshnikov, TV Kobzeva, NE Polyakov… - International journal of …, 2020 - mdpi.com
Ascorbic acid (AscH2) is one of the most important vitamins found in the human diet, with
many biological functions including antioxidant, chelating, and coenzyme activities. Ascorbic …
many biological functions including antioxidant, chelating, and coenzyme activities. Ascorbic …
Promising drug targets and associated therapeutic interventions in Parkinson's disease
Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the
availability of symptomatic treatments, response towards the health of PD patients remains …
availability of symptomatic treatments, response towards the health of PD patients remains …
Polyphenols as potential metal chelation compounds against Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disease affecting more
than 50 million people worldwide. The pathology of this multifactorial disease is primarily …
than 50 million people worldwide. The pathology of this multifactorial disease is primarily …
Influence of heavy metals in Parkinson's disease: an overview
B Vellingiri, A Suriyanarayanan, KS Abraham… - Journal of …, 2022 - Springer
Parkinson's disease (PD) is an ageing disorder with deterioration of dopamine neurons
which leads to motor complications like tremor, stiffness, slow movement and postural …
which leads to motor complications like tremor, stiffness, slow movement and postural …
Metal incorporated sulfonamides as promising multidrug targets: Combined enzyme inhibitory, antimicrobial, antioxidant and theoretical exploration
In this report, new sulfonamide based ligands (L 1)-(L 3) from 4-amino-N-(pyrimidin-2-yl)
benzene-1-sulfonamide are synthesized and branded on the basis of their physical …
benzene-1-sulfonamide are synthesized and branded on the basis of their physical …
Trying to solve the puzzle of the interaction of ascorbic acid and iron: Redox, chelation and therapeutic implications
GJ Kontoghiorghes, A Kolnagou, CN Kontoghiorghe… - Medicines, 2020 - mdpi.com
Iron and ascorbic acid (vitamin C) are essential nutrients for the normal growth and
development of humans, and their deficiency can result in serious diseases. Their …
development of humans, and their deficiency can result in serious diseases. Their …