Persistent SARS-CoV-2 infections may act as viral reservoirs that could seed future
outbreaks,,,–, give rise to highly divergent lineages,–and contribute to cases with post-acute …

Vast amounts of pathogen genomic, demographic and spatial data are transforming our
understanding of SARS-CoV-2 emergence and spread. We examined the drivers of …

Key epidemiological parameters, including the effective reproduction number, R (t), and the
instantaneous growth rate, r (t), generated from an ensemble of models, have been …

Many pathogens evolve to escape immunity, yet it remains difficult to predict whether
immune pressure will lead to diversification, serial replacement of one variant by another, or …

Ongoing SARS-CoV-2 infections are driven by the emergence of various variants, with
differential propensities to escape immune containment. Single nucleotide polymorphisms …

Background/Objectives: This retrospective cohort study evaluated the relative vaccine
effectiveness (rVE) of two bivalent (original/Omicron BA. 4/BA. 5) vaccines mRNA-1273.222 …

Understanding the within-host evolutionary dynamics of SARS-CoV-2, particularly in relation
to variant emergence, is crucial for public health. From a community surveillance study, we …

Botswana, like the rest of the world, has been significantly impacted by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). In December 2022, we detected a …

During the SARS-CoV-2 pandemic, the Dr. Risch medical group employed the multiplex
TaqPathTM COVID-19 CE-IVD RT-PCR Kit for large-scale routine diagnostic testing in …

Since its emergence in late 2019, SARS-CoV-2 has diversified into a large number of
lineages and caused multiple waves of infection globally. Novel lineages have the potential …