[HTML][HTML] Alpha-synuclein aggregation pathway in Parkinson's disease: current status and novel therapeutic approaches

M Vidović, MG Rikalovic - Cells, 2022 - mdpi.com
Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …

Track‐etched nanopore/membrane: from fundamental to applications

T Ma, JM Janot, S Balme - Small Methods, 2020 - Wiley Online Library
Biomimetic and bio‐inspired membranes draw great attention and generate extensive efforts
to solve environmental, health, and energy issues. In this field, track‐etched membranes …

Therapeutic strategies targeting amyloid-β in Alzheimer's disease

L Pinheiro, C Faustino - Current Alzheimer Research, 2019 - ingentaconnect.com
Alzheimer's disease (AD) is a neurodegenerative disorder linked to protein misfolding and
aggregation. AD is pathologically characterized by senile plaques formed by extracellular …

Intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases

O Coskuner-Weber, O Mirzanli, VN Uversky - Biophysical Reviews, 2022 - Springer
Many different intrinsically disordered proteins and proteins with intrinsically disordered
regions are associated with neurodegenerative diseases. These types of proteins including …

Mechanisms of enhanced aggregation and fibril formation of Parkinson's disease-related variants of α-synuclein

T Ohgita, N Namba, H Kono, T Shimanouchi, H Saito - Scientific reports, 2022 - nature.com
Aggregation of α-synuclein (α-syn) into amyloid fibrils is closely associated with Parkinson's
disease (PD). Familial mutations or posttranslational truncations in α-syn are known as risk …

Natural compounds as inhibitors of Aβ peptide aggregation: chemical requirements and molecular mechanisms

K Pagano, S Tomaselli, H Molinari… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, with no
cure and preventive therapy. Misfolding and extracellular aggregation of Amyloid-β (Aβ) …

[HTML][HTML] The molecular mechanisms of the relationship between insulin resistance and Parkinson's disease pathogenesis

VA Ruiz-Pozo, R Tamayo-Trujillo, S Cadena-Ullauri… - Nutrients, 2023 - mdpi.com
Parkinson's disease (PD) is a degenerative condition resulting from the loss of dopaminergic
neurons. This neuronal loss leads to motor and non-motor neurological symptoms. Most PD …

New pathways identify novel drug targets for the prevention and treatment of Alzheimer's disease

B Penke, M Szűcs, F Bogár - International Journal of Molecular Sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disorder. AD is a
complex and multifactorial disease that is responsible for 60–80% of dementia cases. Aging …

Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly

Y Xu, R Maya-Martinez, N Guthertz, GR Heath… - Nature …, 2022 - nature.com
Human islet amyloid polypeptide (hIAPP) self-assembles into amyloid fibrils which deposit in
pancreatic islets of type 2 diabetes (T2D) patients. Here, we applied chemical kinetics to …

Cucurbit [7] uril Macrocyclic Sensors for Optical Fingerprinting: Predicting Protein Structural Changes to Identifying Disease-Specific Amyloid Assemblies

N Das Saha, S Pradhan, R Sasmal… - Journal of the …, 2022 - ACS Publications
In a three-dimensional (3D) representation, each protein molecule displays a specific
pattern of chemical and topological features, which are altered during its misfolding and …