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[HTML][HTML] Alpha-synuclein aggregation pathway in Parkinson's disease: current status and novel therapeutic approaches
Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …
Track‐etched nanopore/membrane: from fundamental to applications
Biomimetic and bio‐inspired membranes draw great attention and generate extensive efforts
to solve environmental, health, and energy issues. In this field, track‐etched membranes …
to solve environmental, health, and energy issues. In this field, track‐etched membranes …
Therapeutic strategies targeting amyloid-β in Alzheimer's disease
L Pinheiro, C Faustino - Current Alzheimer Research, 2019 - ingentaconnect.com
Alzheimer's disease (AD) is a neurodegenerative disorder linked to protein misfolding and
aggregation. AD is pathologically characterized by senile plaques formed by extracellular …
aggregation. AD is pathologically characterized by senile plaques formed by extracellular …
Intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases
Many different intrinsically disordered proteins and proteins with intrinsically disordered
regions are associated with neurodegenerative diseases. These types of proteins including …
regions are associated with neurodegenerative diseases. These types of proteins including …
Mechanisms of enhanced aggregation and fibril formation of Parkinson's disease-related variants of α-synuclein
T Ohgita, N Namba, H Kono, T Shimanouchi, H Saito - Scientific reports, 2022 - nature.com
Aggregation of α-synuclein (α-syn) into amyloid fibrils is closely associated with Parkinson's
disease (PD). Familial mutations or posttranslational truncations in α-syn are known as risk …
disease (PD). Familial mutations or posttranslational truncations in α-syn are known as risk …
Natural compounds as inhibitors of Aβ peptide aggregation: chemical requirements and molecular mechanisms
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, with no
cure and preventive therapy. Misfolding and extracellular aggregation of Amyloid-β (Aβ) …
cure and preventive therapy. Misfolding and extracellular aggregation of Amyloid-β (Aβ) …
[HTML][HTML] The molecular mechanisms of the relationship between insulin resistance and Parkinson's disease pathogenesis
Parkinson's disease (PD) is a degenerative condition resulting from the loss of dopaminergic
neurons. This neuronal loss leads to motor and non-motor neurological symptoms. Most PD …
neurons. This neuronal loss leads to motor and non-motor neurological symptoms. Most PD …
New pathways identify novel drug targets for the prevention and treatment of Alzheimer's disease
B Penke, M Szűcs, F Bogár - International Journal of Molecular Sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disorder. AD is a
complex and multifactorial disease that is responsible for 60–80% of dementia cases. Aging …
complex and multifactorial disease that is responsible for 60–80% of dementia cases. Aging …
Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly
Y Xu, R Maya-Martinez, N Guthertz, GR Heath… - Nature …, 2022 - nature.com
Human islet amyloid polypeptide (hIAPP) self-assembles into amyloid fibrils which deposit in
pancreatic islets of type 2 diabetes (T2D) patients. Here, we applied chemical kinetics to …
pancreatic islets of type 2 diabetes (T2D) patients. Here, we applied chemical kinetics to …
Cucurbit [7] uril Macrocyclic Sensors for Optical Fingerprinting: Predicting Protein Structural Changes to Identifying Disease-Specific Amyloid Assemblies
In a three-dimensional (3D) representation, each protein molecule displays a specific
pattern of chemical and topological features, which are altered during its misfolding and …
pattern of chemical and topological features, which are altered during its misfolding and …