[HTML][HTML] Metabolic-associated fatty liver disease and lipoprotein metabolism
J Heeren, L Scheja - Molecular metabolism, 2021 - Elsevier
Background Non-alcoholic fatty liver disease, or as recently proposed 'metabolic-associated
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …
[HTML][HTML] Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor …
factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor …
Recommendation on design, execution, and reporting of animal atherosclerosis studies: a scientific statement from the American Heart Association
Animal studies are a foundation for defining mechanisms of atherosclerosis and potential
targets of drugs to prevent lesion development or reverse the disease. In the current …
targets of drugs to prevent lesion development or reverse the disease. In the current …
Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction
Myocardial infarction (MI), a leading cause of death around the world, displays a complex
pattern of inheritance,. When MI occurs early in life, genetic inheritance is a major …
pattern of inheritance,. When MI occurs early in life, genetic inheritance is a major …
Common variants associated with plasma triglycerides and risk for coronary artery disease
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary …
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary …
Lipoprotein lipase and its regulators: an unfolding story
Lipoprotein lipase (LPL) is one of the most important factors in systemic lipid partitioning and
metabolism. It mediates intravascular hydrolysis of triglycerides packed in lipoproteins such …
metabolism. It mediates intravascular hydrolysis of triglycerides packed in lipoproteins such …
Brown adipose tissue activity controls triglyceride clearance
Brown adipose tissue (BAT) burns fatty acids for heat production to defend the body against
cold, and has recently been shown to be present in humans,,. Triglyceride-rich lipoproteins …
cold, and has recently been shown to be present in humans,,. Triglyceride-rich lipoproteins …
The effect of heritability and host genetics on the gut microbiota and metabolic syndrome
MY Lim, HJ You, HS Yoon, B Kwon, JY Lee, S Lee… - Gut, 2017 - gut.bmj.com
Objective Metabolic syndrome (MetS) arises from complex interactions between host genetic
and environmental factors. Although it is now widely accepted that the gut microbiota plays a …
and environmental factors. Although it is now widely accepted that the gut microbiota plays a …
Phenomics: the next challenge
A key goal of biology is to understand phenotypic characteristics, such as health, disease
and evolutionary fitness. Phenotypic variation is produced through a complex web of …
and evolutionary fitness. Phenotypic variation is produced through a complex web of …
Apoa5 Q139X truncation predisposes to late-onset hyperchylomicronemia due to lipoprotein lipase impairment
C Marçais, B Verges, S Charrière… - The Journal of …, 2005 - Am Soc Clin Investig
While type 1 hyperlipidemia is associated with lipoprotein lipase or apoCII deficiencies, the
etiology of type 5 hyperlipidemia remains largely unknown. We explored a new candidate …
etiology of type 5 hyperlipidemia remains largely unknown. We explored a new candidate …