Wound healing: cellular mechanisms and pathological outcomes
Wound healing is a complex, dynamic process supported by a myriad of cellular events that
must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound …
must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound …
Tumour-associated macrophages as treatment targets in oncology
Macrophages are crucial drivers of tumour-promoting inflammation. Tumour-associated
macrophages (TAMs) contribute to tumour progression at different levels: by promoting …
macrophages (TAMs) contribute to tumour progression at different levels: by promoting …
[HTML][HTML] A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells
Tumor-infiltrating myeloid cells (TIMs) are key regulators in tumor progression, but the
similarity and distinction of their fundamental properties across different tumors remain …
similarity and distinction of their fundamental properties across different tumors remain …
Single-cell spatial immune landscapes of primary and metastatic brain tumours
Single-cell technologies have enabled the characterization of the tumour microenvironment
at unprecedented depth and have revealed vast cellular diversity among tumour cells and …
at unprecedented depth and have revealed vast cellular diversity among tumour cells and …
Neutrophil phenotypes and functions in cancer: A consensus statement
Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …
component of innate immune defense. Understanding the behavior of neutrophils as they …
Single-cell spatial landscapes of the lung tumour immune microenvironment
Single-cell technologies have revealed the complexity of the tumour immune
microenvironment with unparalleled resolution,,,,,,,–. Most clinical strategies rely on …
microenvironment with unparalleled resolution,,,,,,,–. Most clinical strategies rely on …
Macrophage polarization
PJ Murray - Annual review of physiology, 2017 - annualreviews.org
Macrophage polarization refers to how macrophages have been activated at a given point in
space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate …
space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate …
Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species
Tumor-infiltrating myeloid cells (TIMs) comprise monocytes, macrophages, dendritic cells,
and neutrophils, and have emerged as key regulators of cancer growth. These cells can …
and neutrophils, and have emerged as key regulators of cancer growth. These cells can …
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation
The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …
Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2
Background Macrophages are innate immune cells with diverse functional and molecular
phenotypes. This diversity is largely unexplored at the level of single-cell proteomes …
phenotypes. This diversity is largely unexplored at the level of single-cell proteomes …