Impact of Microbiome–Brain Communication on Neuroinflammation and Neurodegeneration
I Stolzer, E Scherer, P Süß, V Rothhammer… - International Journal of …, 2023 - mdpi.com
The gut microbiome plays a pivotal role in maintaining human health, with numerous studies
demonstrating that alterations in microbial compositions can significantly affect the …
demonstrating that alterations in microbial compositions can significantly affect the …
[HTML][HTML] Pathogenesis, diagnostics, and therapeutics for Alzheimer's disease: Breaking the memory barrier
Alzheimer's disease (AD) is the most common cause of dementia and accounts for 60–70%
of all cases. It affects millions of people worldwide. AD poses a substantial economic burden …
of all cases. It affects millions of people worldwide. AD poses a substantial economic burden …
New cyclophilin D inhibitor rescues mitochondrial and cognitive function in Alzheimer's disease
Mitochondrial dysfunction is an early pathological feature of Alzheimer disease and plays a
crucial role in the development and progression of Alzheimer's disease. Strategies to rescue …
crucial role in the development and progression of Alzheimer's disease. Strategies to rescue …
Evaluation of neurodegenerative disorders with amyloid-β, tau, and dopaminergic PET imaging: Interpretation pitfalls
BJ Burkett, DR Johnson… - Journal of Nuclear …, 2024 - jnm.snmjournals.org
Antiamyloid therapies for Alzheimer disease recently entered clinical practice, making
imaging biomarkers for Alzheimer disease even more relevant to guiding patient …
imaging biomarkers for Alzheimer disease even more relevant to guiding patient …
Switching on/off amyloid plaque formation in transgenic animal models of Alzheimer's disease
A hallmark of Alzheimer's disease (AD) are the proteinaceous aggregates formed by the
amyloid-beta peptide (Aβ) that is deposited inside the brain as amyloid plaques. The …
amyloid-beta peptide (Aβ) that is deposited inside the brain as amyloid plaques. The …
Multi-target-directed therapeutic strategies for Alzheimer's disease: controlling amyloid-β aggregation, metal ion homeostasis, and enzyme inhibition
Alzheimer's disease (AD) is the most prevalent neurodegenerative dementia, marked by
progressive cognitive decline and memory impairment. Despite advances in therapeutic …
progressive cognitive decline and memory impairment. Despite advances in therapeutic …
Association of modifiable risk factors with progression to dementia in relation to amyloid and tau pathology
Background Dementia preventive interventions targeting multiple modifiable risk factors are
a promising approach. However, the impact of modifiable risk factors in the presence of beta …
a promising approach. However, the impact of modifiable risk factors in the presence of beta …
Amyloid‐related imaging abnormalities (ARIA): diagnosis, management, and care in the setting of amyloid‐modifying therapy
RB Vukmir - Annals of clinical and translational neurology, 2024 - Wiley Online Library
Amyloid‐related imaging abnormalities, were originally described by dementia care experts.
The wider use of aducanumab and now lecanemab warrant broader understanding by the …
The wider use of aducanumab and now lecanemab warrant broader understanding by the …
Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer's Disease Management
Alzheimer's disease, a progressive neurodegenerative condition, is characterized by a
gradual decline in cognitive functions. Current treatment approaches primarily involve the …
gradual decline in cognitive functions. Current treatment approaches primarily involve the …
Altered metabolism and DAM-signatures in female brains and microglia with aging
NRW Cleland, GJ Potter, C Buck, D Quang, D Oldham… - Brain Research, 2024 - Elsevier
Despite Alzheimer's disease (AD) disproportionately affecting women, the mechanisms
remain elusive. In AD, microglia undergo 'metabolic reprogramming', which contributes to …
remain elusive. In AD, microglia undergo 'metabolic reprogramming', which contributes to …