Impact of Microbiome–Brain Communication on Neuroinflammation and Neurodegeneration

I Stolzer, E Scherer, P Süß, V Rothhammer… - International Journal of …, 2023 - mdpi.com
The gut microbiome plays a pivotal role in maintaining human health, with numerous studies
demonstrating that alterations in microbial compositions can significantly affect the …

[HTML][HTML] Pathogenesis, diagnostics, and therapeutics for Alzheimer's disease: Breaking the memory barrier

PT Kamatham, R Shukla, DK Khatri, LK Vora - Ageing research reviews, 2024 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and accounts for 60–70%
of all cases. It affects millions of people worldwide. AD poses a substantial economic burden …

New cyclophilin D inhibitor rescues mitochondrial and cognitive function in Alzheimer's disease

S Samanta, F Akhter, A Roy, D Chen, B Turner, Y Wang… - Brain, 2024 - academic.oup.com
Mitochondrial dysfunction is an early pathological feature of Alzheimer disease and plays a
crucial role in the development and progression of Alzheimer's disease. Strategies to rescue …

Evaluation of neurodegenerative disorders with amyloid-β, tau, and dopaminergic PET imaging: Interpretation pitfalls

BJ Burkett, DR Johnson… - Journal of Nuclear …, 2024 - jnm.snmjournals.org
Antiamyloid therapies for Alzheimer disease recently entered clinical practice, making
imaging biomarkers for Alzheimer disease even more relevant to guiding patient …

Switching on/off amyloid plaque formation in transgenic animal models of Alzheimer's disease

SA Kozin, OI Kechko, AA Adzhubei… - International Journal of …, 2023 - mdpi.com
A hallmark of Alzheimer's disease (AD) are the proteinaceous aggregates formed by the
amyloid-beta peptide (Aβ) that is deposited inside the brain as amyloid plaques. The …

Multi-target-directed therapeutic strategies for Alzheimer's disease: controlling amyloid-β aggregation, metal ion homeostasis, and enzyme inhibition

J Yoo, J Lee, B Ahn, J Han, MH Lim - Chemical Science, 2025 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative dementia, marked by
progressive cognitive decline and memory impairment. Despite advances in therapeutic …

Association of modifiable risk factors with progression to dementia in relation to amyloid and tau pathology

Z Huszár, A Solomon, MA Engh, V Koszovácz… - Alzheimer's Research & …, 2024 - Springer
Background Dementia preventive interventions targeting multiple modifiable risk factors are
a promising approach. However, the impact of modifiable risk factors in the presence of beta …

Amyloid‐related imaging abnormalities (ARIA): diagnosis, management, and care in the setting of amyloid‐modifying therapy

RB Vukmir - Annals of clinical and translational neurology, 2024 - Wiley Online Library
Amyloid‐related imaging abnormalities, were originally described by dementia care experts.
The wider use of aducanumab and now lecanemab warrant broader understanding by the …

Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer's Disease Management

S Dighe, S Jog, M Momin, S Sawarkar, A Omri - Pharmaceutics, 2023 - mdpi.com
Alzheimer's disease, a progressive neurodegenerative condition, is characterized by a
gradual decline in cognitive functions. Current treatment approaches primarily involve the …

Altered metabolism and DAM-signatures in female brains and microglia with aging

NRW Cleland, GJ Potter, C Buck, D Quang, D Oldham… - Brain Research, 2024 - Elsevier
Despite Alzheimer's disease (AD) disproportionately affecting women, the mechanisms
remain elusive. In AD, microglia undergo 'metabolic reprogramming', which contributes to …