Mechanisms of DNA damage, repair, and mutagenesis
Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …
impact health and modulate disease‐states. However, robust DNA repair and damage …
[HTML][HTML] Sunlight damage to cellular DNA: Focus on oxidatively generated lesions
The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one
of the most significant environmental DNA-damaging agents to which humans are exposed …
of the most significant environmental DNA-damaging agents to which humans are exposed …
Understanding nucleotide excision repair and its roles in cancer and ageing
Nucleotide excision repair (NER) eliminates various structurally unrelated DNA lesions by a
multiwise'cut and patch'-type reaction. The global genome NER (GG-NER) subpathway …
multiwise'cut and patch'-type reaction. The global genome NER (GG-NER) subpathway …
Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability
J Sollier, CT Stork, ML García-Rubio, RD Paulsen… - Molecular cell, 2014 - cell.com
R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are
physiological structures that regulate various cellular processes occurring on chromatin …
physiological structures that regulate various cellular processes occurring on chromatin …
DNA repair mechanisms in dividing and non-dividing cells
T Iyama, DM Wilson III - DNA repair, 2013 - Elsevier
DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple
forms, and if allowed to persist, can promote genome instability and directly lead to various …
forms, and if allowed to persist, can promote genome instability and directly lead to various …
DNA damage and associated DNA repair defects in disease and premature aging
Genetic information is constantly being attacked by intrinsic and extrinsic damaging agents,
such as reactive oxygen species, atmospheric radiation, environmental chemicals, and …
such as reactive oxygen species, atmospheric radiation, environmental chemicals, and …
Nucleotide excision repair in humans
G Spivak - DNA repair, 2015 - Elsevier
The demonstration of DNA damage excision and repair replication by Setlow, Howard-
Flanders, Hanawalt and their colleagues in the early 1960s, constituted the discovery of the …
Flanders, Hanawalt and their colleagues in the early 1960s, constituted the discovery of the …
Molecular mechanisms of ultraviolet radiation‐induced DNA damage and repair
RP Rastogi, null Richa, A Kumar… - Journal of nucleic …, 2010 - Wiley Online Library
DNA is one of the prime molecules, and its stability is of utmost importance for proper
functioning and existence of all living systems. Genotoxic chemicals and radiations exert …
functioning and existence of all living systems. Genotoxic chemicals and radiations exert …
Heterochromatin: an epigenetic point of view in aging
Aging is an inevitable process of life. Defined by progressive physiological and functional
loss of tissues and organs, aging increases the risk of mortality for the organism. The aging …
loss of tissues and organs, aging increases the risk of mortality for the organism. The aging …
DNA damage and repair in plants–from models to crops
V Manova, D Gruszka - Frontiers in plant science, 2015 - frontiersin.org
The genomic integrity of every organism is constantly challenged by endogenous and
exogenous DNA-damaging factors. Mutagenic agents cause reduced stability of plant …
exogenous DNA-damaging factors. Mutagenic agents cause reduced stability of plant …