Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …

The potential roles of breast cancer stem cells (BCSCs) in tumor initiation and recurrence
have been recognized for many decades. Due to their strong capacity for self-renewal and …

Immunomodulatory effects of long-chain fatty acids (LCFAs) and their activating enzyme,
acyl-coenzyme A (CoA) synthetase long-chain family (ACSL), in the tumor microenvironment …

Due to a lack of research on the critical non-coding RNAs in regulating ferroptosis, our study
aimed to uncover the crucial ones involved in the process. We found that LINC01133 could …

Several studies indicate a strong link between obesity and the risk of breast cancer. Obesity
decreases gut microbial biodiversity and modulates Bacteroidetes-to-Firmicutes phyla …

Breast tumorigenesis relies on complex interactions between tumor cells and their
surrounding microenvironment, orchestrated by tightly regulated transcriptional networks …

Develo** novel therapeutics often follows three steps: target identification, design of
strategies to suppress target activity and drug development to implement the strategies. In …

Deregulation of E3 ubiquitin ligases drives the proliferation and metastasis of various
cancers; however, the underlying mechanisms remain unknown. This study aimed to …

Genome-wide association studies (GWASs) have identified over 140 colorectal cancer
(CRC)-associated loci; however, target genes at the majority of loci and underlying …

Fatty acids have an important place in both biological and nutritional contexts and, from a
clinical point of view, they have known consequences for diseases' onset and development …