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In Vivo Metabolic Imaging of [1‐13C]Pyruvate‐d3 Hyperpolarized By Reversible Exchange With Parahydrogen**
Metabolic magnetic resonance imaging (MRI) using hyperpolarized (HP) pyruvate is
becoming a non‐invasive technique for diagnosing, staging, and monitoring response to …
becoming a non‐invasive technique for diagnosing, staging, and monitoring response to …
Parahydrogen-based NMR signal amplification by reversible exchange (SABRE): Recent advances and applications
Signal amplification by reversible exchange (SABRE) is a rapidly develo** nuclear
magnetic resonance (NMR) hyperpolarization technique utilizing parahydrogen for dramatic …
magnetic resonance (NMR) hyperpolarization technique utilizing parahydrogen for dramatic …
MATRESHCA: Microtesla Apparatus for Transfer of Resonance Enhancement of Spin Hyperpolarization via Chemical Exchange and Addition
We present an integrated, open-source device for parahydrogen-based hyperpolarization
processes in the microtesla field regime with a cost of components of less than $7000. The …
processes in the microtesla field regime with a cost of components of less than $7000. The …
Long-lived enhanced magnetization—A practical metabolic MRI contrast material
Noninvasive tracking of biochemical processes in the body is paramount in diagnostic
medicine. Among the leading techniques is spectroscopic magnetic resonance imaging …
medicine. Among the leading techniques is spectroscopic magnetic resonance imaging …
[HTML][HTML] Quo Vadis Hyperpolarized 13C MRI?
Over the last two decades, hyperpolarized 13 C MRI has gained significance in both
preclinical and clinical studies, hereby relying on technologies like PHIP-SAH …
preclinical and clinical studies, hereby relying on technologies like PHIP-SAH …
Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation of the Hyperpolarized Ketone and Hemiketal Forms of Allyl [1-13C]Pyruvate
13C hyperpolarized pyruvate is an emerging MRI contrast agent for sensing molecular
events in cancer and other diseases with aberrant metabolic pathways. This metabolic …
events in cancer and other diseases with aberrant metabolic pathways. This metabolic …
Real‐Time Metabolic Magnetic Resonance Spectroscopy of Pancreatic and Colon Cancer Tumor‐Xenografts with Parahydrogen Hyperpolarized 1‐13C Pyruvate‐d3
LM Fries, TLK Hune, S Sternkopf… - … A European Journal, 2024 - Wiley Online Library
Parahydrogen‐induced polarization (PHIP) is an emerging technique to enhance the signal
of stable isotope metabolic contrast agents for Magnetic Resonance (MR). The objective of …
of stable isotope metabolic contrast agents for Magnetic Resonance (MR). The objective of …
Hyperpolarizing Small Molecules using Parahydrogen and Solid‐State Spin Diffusion
Parahydrogen‐induced polarization (PHIP) is an inexpensive way to produce
hyperpolarized molecules with polarization levels of> 10% in the solution‐state, but is …
hyperpolarized molecules with polarization levels of> 10% in the solution‐state, but is …
Enhanced Solubility and Polarization of 13C-Fumarate with Meglumine Allows for In Vivo Detection of Gluconeogenic Metabolism in Kidneys
Hyperpolarized 13C-labeled fumarate probes tissue necrosis via the production of 13C-
malate. Despite its promises in detecting tumor necrosis and kidney injuries, its clinical …
malate. Despite its promises in detecting tumor necrosis and kidney injuries, its clinical …
[HTML][HTML] Hyperpolarization of [13C] formate using parahydrogen
DB Burueva, SV Sviyazov, NV Chukanov… - Journal of Magnetic …, 2024 - Elsevier
Sodium [13 C] formate was successfully hyperpolarized using parahydrogen-induced
polarization by means of side-arm hydrogenation (PHIP-SAH). Allyl [13 C] formate was …
polarization by means of side-arm hydrogenation (PHIP-SAH). Allyl [13 C] formate was …