[HTML][HTML] Molecular tinkering of G protein‐coupled receptors: an evolutionary success
Among membrane‐bound receptors, the G protein‐coupled receptors (GPCRs) are certainly
the most diverse. They have been very successful during evolution, being capable of …
the most diverse. They have been very successful during evolution, being capable of …
The pharmacology and clinical pharmacology of 3, 4-methylenedioxymethamphetamine (MDMA,“ecstasy”)
AR Green, AO Mechan, JM Elliott, E O'Shea… - Pharmacological …, 2003 - Elsevier
Abstract The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA,
ecstasy) is a popular recreational drug among young people, particularly those involved in …
ecstasy) is a popular recreational drug among young people, particularly those involved in …
G-protein-coupled receptor heterodimerization modulates receptor function
The opioid system modulates several physiological processes, including analgesia, the
stress response, the immune response and neuroendocrine function. Pharmacological and …
stress response, the immune response and neuroendocrine function. Pharmacological and …
The neurobiology and control of anxious states
MJ Millan - Progress in neurobiology, 2003 - Elsevier
Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …
(external and internal) stimuli which threaten to perturb homeostasis. However, when …
Uncovering molecular mechanisms involved in activation of G protein-coupled receptors
U Gether - Endocrine reviews, 2000 - academic.oup.com
G protein-coupled, seven-transmembrane segment receptors (GPCRs or 7TM receptors),
with more than 1000 different members, comprise the largest superfamily of proteins in the …
with more than 1000 different members, comprise the largest superfamily of proteins in the …
Mutations in the human Ca2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
MR Pollak, EM Brown, YHW Chou, SC Hebert, SJ Marx… - Cell, 1993 - cell.com
We demonstrate that mutations in the human Ca*+-sensing receptor gene cause familial
hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT), two …
hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT), two …
Detection of β2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)
Heptahelical receptors that interact with heterotrimeric G proteins represent the largest
family of proteins involved in signal transduction across biological membranes. Although …
family of proteins involved in signal transduction across biological membranes. Although …
Retinylidene proteins: structures and functions from archaea to humans
▪ Abstract Retinylidene proteins, containing seven membrane-embedded α-helices that form
an internal pocket in which the chromophore retinal is bound, are ubiquitous in …
an internal pocket in which the chromophore retinal is bound, are ubiquitous in …
Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis …
K Kristiansen - Pharmacology & therapeutics, 2004 - Elsevier
The superfamily of G-protein-coupled receptors (GPCRs) could be subclassified into 7
families (A, B, large N-terminal family B-7 transmembrane helix, C, Frizzled/Smoothened …
families (A, B, large N-terminal family B-7 transmembrane helix, C, Frizzled/Smoothened …
G-protein-coupled receptor oligomerization and its potential for drug discovery
SR George, BF O'Dowd, SP Lee - Nature reviews Drug discovery, 2002 - nature.com
G-protein-coupled receptors (GPCRs) represent by far the largest class of targets for modern
drugs. Virtually all therapeutics that are directed towards GPCRs have been designed using …
drugs. Virtually all therapeutics that are directed towards GPCRs have been designed using …