Molecular mechanisms underlying neurotransmitter release
J Rizo - Annual Review of Biophysics, 2022 - annualreviews.org
Major recent advances and previous data have led to a plausible model of how key proteins
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …
Fluid biomarkers for synaptic dysfunction and loss
E Camporesi, J Nilsson, A Brinkmalm… - Biomarker …, 2020 - journals.sagepub.com
Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …
neurons and stored for memory formation. Synaptic degeneration is a global and early …
SNAREopathies: diversity in mechanisms and symptoms
M Verhage, JB Sørensen - Neuron, 2020 - cell.com
Neuronal SNAREs and their key regulators together drive synaptic vesicle exocytosis and
synaptic transmission as a single integrated membrane fusion machine. Human pathogenic …
synaptic transmission as a single integrated membrane fusion machine. Human pathogenic …
[HTML][HTML] N-glycoproteomics of brain synapses and synaptic vesicles
At mammalian neuronal synapses, synaptic vesicle (SV) glycoproteins are essential for
robust neurotransmission. Asparagine (N)-linked glycosylation is required for delivery of the …
robust neurotransmission. Asparagine (N)-linked glycosylation is required for delivery of the …
Disorders of synaptic vesicle fusion machinery
The revolution in genetic technology has ushered in a new age for our understanding of the
underlying causes of neurodevelopmental, neuromuscular and neurodegenerative …
underlying causes of neurodevelopmental, neuromuscular and neurodegenerative …
Molecular basis for synaptotagmin-1-associated neurodevelopmental disorder
Summary At neuronal synapses, synaptotagmin-1 (syt1) acts as a Ca 2+ sensor that
synchronizes neurotransmitter release with Ca 2+ influx during action potential firing …
synchronizes neurotransmitter release with Ca 2+ influx during action potential firing …
A lever hypothesis for Synaptotagmin-1 action in neurotransmitter release
Neurotransmitter release is triggered in microseconds by Ca2+-binding to the
Synaptotagmin-1 C2-domains and by SNARE complexes that form four-helix bundles …
Synaptotagmin-1 C2-domains and by SNARE complexes that form four-helix bundles …
Recent insights into beta-cell exocytosis in type 2 diabetes
As one of the leading causes of morbidity and mortality worldwide, diabetes affects an
estimated 422 million adults, and it is expected to continue expanding such that by 2050 …
estimated 422 million adults, and it is expected to continue expanding such that by 2050 …
Syntaxin-1A modulates vesicle fusion in mammalian neurons via juxtamembrane domain dependent palmitoylation of its transmembrane domain
G Vardar, A Salazar-Lázaro, S Zobel, T Trimbuch… - Elife, 2022 - elifesciences.org
SNAREs are undoubtedly one of the core elements of synaptic transmission. Contrary to the
well characterized function of their SNARE domains bringing the plasma and vesicular …
well characterized function of their SNARE domains bringing the plasma and vesicular …
Synaptotagmin-1 undergoes phase separation to regulate its calcium-sensitive oligomerization
M Zhu, H Xu, Y **, X Kong, B Xu, Y Liu, H Yu - Journal of Cell Biology, 2024 - rupress.org
Synaptotagmin-1 (Syt1) is a calcium sensor that regulates synaptic vesicle fusion in
synchronous neurotransmitter release. Syt1 interacts with negatively charged lipids and the …
synchronous neurotransmitter release. Syt1 interacts with negatively charged lipids and the …