Mechanisms of Polycomb group protein function in cancer
V Parreno, AM Martinez, G Cavalli - Cell research, 2022 - nature.com
Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …
Six years (2012–2018) of researches on catalytic ezh2 inhibitors: the boom of the 2‐pyridone compounds
R Fioravanti, G Stazi, C Zwergel… - The Chemical …, 2018 - Wiley Online Library
Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive
complex 2 (PRC2), catalyzes the methylation of lysine 27 of histone H3 (H3K27) up to its …
complex 2 (PRC2), catalyzes the methylation of lysine 27 of histone H3 (H3K27) up to its …
MEK inhibition induces MYOG and remodels super-enhancers in RAS-driven rhabdomyosarcoma
The RAS isoforms are frequently mutated in many types of human cancers, including
PAX3/PAX7 fusion-negative rhabdomyosarcoma. Pediatric RMS arises from skeletal muscle …
PAX3/PAX7 fusion-negative rhabdomyosarcoma. Pediatric RMS arises from skeletal muscle …
Concise review: epigenetic regulation of myogenesis in health and disease
Skeletal muscle regeneration is initiated by satellite cells, a population of adult stem cells
that reside in the muscle tissue. The ability of satellite cells to self-renew and to differentiate …
that reside in the muscle tissue. The ability of satellite cells to self-renew and to differentiate …
Insights into pediatric rhabdomyosarcoma research: Challenges and goals
Overall survival rates for pediatric patients with high‐risk or relapsed rhabdomyosarcoma
(RMS) have not improved significantly since the 1980s. Recent studies have identified a …
(RMS) have not improved significantly since the 1980s. Recent studies have identified a …
Pediatric rhabdomyosarcoma
Rhabdomyosarcoma is the most common soft-tissue sarcoma of childhood, and despite
clinical advances, subsets of these patients continue to suffer high levels of morbidity and …
clinical advances, subsets of these patients continue to suffer high levels of morbidity and …
[HTML][HTML] Targeting EZH2 in neuroblastoma
Neuroblastoma is one of the commonest extra-cranial pediatric tumors, and accounts for
over 15% of all childhood cancer mortality. Risk stratification for children with neuroblastoma …
over 15% of all childhood cancer mortality. Risk stratification for children with neuroblastoma …
Soft tissue sarcoma cancer stem cells: an overview
Soft tissue sarcomas (STSs) are an uncommon group of solid tumors that can arise
throughout the human lifespan. Despite their commonality as non-bony cancers that develop …
throughout the human lifespan. Despite their commonality as non-bony cancers that develop …
CD73 contributes to the pathogenesis of fusion-negative rhabdomyosarcoma through the purinergic signaling pathway
KC Hernandez, AM Shah, VA Lopez… - Proceedings of the …, 2024 - National Acad Sciences
Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children and
adolescents. Fusion-negative RMS (FN-RMS) accounts for more than 80% of all RMS cases …
adolescents. Fusion-negative RMS (FN-RMS) accounts for more than 80% of all RMS cases …
[HTML][HTML] EZH2 promotes colorectal cancer stem-like cell expansion by activating p21cip1-Wnt/β-catenin signaling
JF Chen, X Luo, LS **ang, HT Li, L Zha, N Li, JM He… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Because colorectal cancer (CRC) stem-like cells (CCS-like cells) contribute to poor patient
prognosis, these cells are a potential target for CRC therapy. However, the mechanism …
prognosis, these cells are a potential target for CRC therapy. However, the mechanism …